男性非肥胖2型糖尿病患者糖化血红蛋白与睾酮水平的相关性

目的探讨男性非肥胖2型糖尿病(T2DM)患者糖化血红蛋白(HbA_1c)和血清总睾酮(TT)水平的相关性。 方法选取2019年11月至2021年4月于济宁医学院附属医院内分泌科住院治疗的387例男性非肥胖T2DM患者，收集其基线临床资料，根据HbA_1c水平四分位数分组，比较4组间TT水平的差异；采用Pearson相关分析及多元线性回归分析男性非肥胖T2DM患者HbA_1c与TT水平的相关性。 结果男性非肥胖T2DM患者TT水平为3.97(3.06，4.98)ng/mL，睾酮缺乏(<3.5 ng/mL)的患者占36.43%(141/387)，平均HbA_1c水平为(8.99±1.98)%，按照HbA_1c水平四分位数分组，发现随着HbA_1c水平的升高，TT水平呈下降趋势，差异有统计学意义(F＝2.99，P<0.05)。经Pearson相关分析结果显示TT与HbA_1c(r＝－0.13)、腰围(r＝－0.14)、腰臀比(WHT)(r＝－0.12)、甘油三酯(TG)(r＝－0.16)、空腹C肽(r＝－0.24)呈负相关关系，与高密度脂蛋白胆固醇(HDL-C)(r＝0.19)呈正相关关系(均P<0.05)。将TT与HbA_1c、年龄、腰围、WHT、HDL-C、TG、空腹C肽纳入多元线性回归分析，结果显示男性非肥胖T2DM患者的HbA_1c与TT仍呈显著负相关关系(B＝－0.18，P<0.01)。 结论在男性非肥胖T2DM患者中，HbA_1c与TT水平呈独立负相关。

Correlation between glycosylated hemoglobin and testosterone in non-obese male patients with type 2 diabetes mellitus

ObjectiveTo investigate the correlation between glycosylated hemoglobin (HbA_1c)and serum total testosterone (TT) level in non-obese male patients with type 2 diabetes mellitus (T2DM). MethodsA total of 387 non-obese male T2DM patients hospitalized in the Endocrinology Department, Affiliated Hospital of Jining Medical University from November 2019 to April 2021 were selected. Their baseline clinical data were collected and grouped according to the quartile of HbA_1c level to compare the differences of TT levels among the four groups. The link between HbA_1c and TT level was investigated using Pearson correlation analysis and multiple linear regression. ResultsThe TT level was 3.97 (3.06, 4.98)ng/mL in non-obese male T2DM patients, with testosterone insufficiency (<3.5 ng/mL) accounting for 36.43%(141/387). According to the quartile of HbA_1c level, TT levels decreased as HbA_1c levels increased, and the difference was statistically significant (F=2.99, P<0.05). Pearson correlation analysis showed that TT was negatively correlated with HbA_1c (r=-0.13), waist circumference (r=-0.14), WHT (r=-0.12), TG (r=-0.16), fasting C-peptide (r=-0.24), and positively correlated with HDL-C (r=0.19) (all P<0.05). Multiple linear regression analysis included TT and HbA_1c, age, waist circumference, WHT, HDL-C, TG, and fasting C-peptide. In non-obese male T2DM patients, HbA_1c was found to be significantly adversely linked with TT (B=-0.18, P<0.01). ConclusionIn non-obese male T2DM patients, HbA_1c is inversely linked with TT level.