| 线粒体自噬的调控机制及其在脑缺血再灌注损伤中的作用 |
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| 引用本文： | 谢佳佳,孙婷,张丹参. 线粒体自噬的调控机制及其在脑缺血再灌注损伤中的作用[J]. 神经药理学报, 2021, 11(3): 43-49. DOI: 10.3969/j.issn.2095-1396.2021.03.008 |
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| 作者姓名： | 谢佳佳 孙婷 张丹参 |
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| 作者单位： | 河北科技大学化学与制药工程学院，石家庄，050018，中国 |
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| 基金项目： | 河北省重点研发计划项目生物医药专项（No.20372509D），河北省自然科学基金（No.H2020208032），河北省高等学校科学技术研究项目（No.ZD2020117），河北省中医药管理局中医药科研计划项目（No.2020268），中央财政公共卫生专项“中药资源普查项目”（No.Z135080000022） |
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| 摘 要： | 自噬作为参与细胞代谢和细胞器更新的调节机制,在机体的生理和病理过程中扮演着重要的角色.线粒体自噬作为细胞靶物特异性自噬的一种,可识别和清除功能受损的线粒体,实现线粒体的质量控制.线粒体主要通过Parkin依赖途径和非Parkin依赖途径调节自噬,从而影响机体的机能.研究表明线粒体自噬与脑缺血再灌注损伤过程有密切的关系,...
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| 关 键 词： | 线粒体自噬 线粒体自噬机制 脑缺血再灌注损伤 |
Regulation of Mitochondrial Autophagy and Its Role in Cerebral Ischemia-Reperfusion Injury |
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| XIE Jia-jia,SUN Ting,ZHANG Dan-shen. Regulation of Mitochondrial Autophagy and Its Role in Cerebral Ischemia-Reperfusion Injury[J]. Journal of Hebei North University(Medical Edition), 2021, 11(3): 43-49. DOI: 10.3969/j.issn.2095-1396.2021.03.008 |
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| Authors: | XIE Jia-jia SUN Ting ZHANG Dan-shen |
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| Affiliation: | College of Chemical and Pharmaceutical Engineering，Hebei University of Science and Technology，Shijiazhuang，050018，China
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| Abstract: | As a regulatory mechanism involved in cell metabolism and organelle renewal，autophagy plays an important role in the physiological and pathological processes of the body. Mitophagy，as a type of cell target-specific autophagy，can identify and remove functionally impaired mitochondria and achieve mitochondrial quality control. Mitochondria mainly regulate autophagy through Parkin-dependent and non-Parkin-dependent pathways，thereby affecting the body’s function. Studies have shown that mitochondrial autophagy is closely related to the process of cerebral ischemia-reperfusion injury，but its role in cerebral ischemia-reperfusion injury has been controversial. This article mainly summarizes the mechanism of mitochondrial autophagy and the way in which mitochondrial autophagy participates in cerebral ischemia-reperfusion injury. |
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| Keywords: | mitophagy mitophagy mechanism cerebral ischemia reperfusion injury |
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