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国产与进口美百乐镇治疗高胆固醇血症效果比较
引用本文:(Mevalotin Collaborative Group). 国产与进口美百乐镇治疗高胆固醇血症效果比较[J]. 中国循环杂志, 1994, 0(11)
作者姓名:(Mevalotin Collaborative Group)
摘    要:本文用随机双盲安慰剂对照临床试验方法,观察比较了国产美百乐镇(汕头陀滨制药厂)与进口美百乐镇(日本三共株式会社)治疗高胆固醇血症患者的效果。结果表明,国产和进口美百乐镇均可显著降低血清总胆固醇和低密度脂蛋白胆固醇水平,降总胆固醇个体疗效的总有效率分别达88.6%、88.7%;对血清甘油三酯也有轻度降低作用;对高密度脂蛋白胆固醇水平影响不大。副作用小,服用方便,有临床应用价值。

关 键 词:美百乐镇,高胆固醇血症,血脂

COMPARATIVE EFFECTS OF DOMESTIC AND IMPORTED MEVALOTIN ON HYPERCHOLESTEROLEMIA
Affiliation:(Mevalotin Collaborative Group
Abstract:The study was designed in randomized, doubleblind,placebo-controlled clinical trial to investigate the effects of domestic (Tuobin Company in China) and imported (Sankyo Company in Japan) mevalotin (pravastatin) on patients with hypercholesterolemia.The results revealed that both serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels were reduced significantly by domestic (n= 123) and imported (n = 53) mevalotin compared with placebo (n= 15). The total effective rate of decreasing TC was 88. 6% and 88. 7% with domestic and imported mevalotin, respectively. The serum triglycerides (TG) were slightly lowered by both mevalotins,but high-density lipoprotein cholesterol (HDL-C) levels showed no marked change. The side effects were few witb both. The results indicated that the improvement of serum lipid values was similar with domestic compared with imported mevalotin on Chinese patients with hypercholesterolemia.
Keywords:Mevalotin  Hypercholesterolemia  
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