Nongenomic oestrogen signalling in oestrogen receptor negative breast cancer cells: a role for the angiotensin II receptor AT1 |
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| Authors: | Kheng Tian Lim Niamh Cosgrave Arnold David Hill Leonie S Young |
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| Affiliation: | (1) School of Medicine and Medical Science, St. Vincent's University Hospital, Elm Park, Dublin, Ireland;(2) School of Medicine and Medical Science, UCD Conway Institute of Biomolecular and Biomedical Research, UCD Conway Institute, University College Dublin, Dublin, Ireland |
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| Abstract: | ![]()
Introduction Oestrogens can mediate some of their cell survival properties through a nongenomic mechanism that involves the mitogen-activated protein kinase (MAPK) pathway. The mechanism of this rapid signalling and its dependence on a membrane bound oestrogen receptor (ER), however, remains controversial. The role of G-protein-coupled receptor and epidermal growth factor (EGF) receptor in an ER-independent signalling pathway modulated by oestrogen was investigated. |
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