阿卡波糖与格列美脲联合治疗新诊断2型糖尿病的疗效观察

【目的】观察阿卡波糖（拜唐苹）和格列美脲联合治疗新诊断2型糖尿病的疗效及安全性。【方法】收集2008年6月至2009年2月本院专科门诊及住院病人中新诊断2型糖尿病患者共65例,予阿卡波糖（拜唐苹）和格列美脲联合治疗,治疗前及治疗12周后测定体重指数（BMI）、空腹血糖（FBG）、餐后血糖（PBG）、糖化血红蛋白（HbAlc）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL—C）、肝肾功能,同时观察药物副作用。【结果】治疗12周后血糖及血脂指标较治疗前有明显改善,低血糖反应发生率6．7％,无严重低血糖事件发生。【结论】阿卡波糖（拜唐苹）与格列美脲联合治疗新诊断2型糖尿病控制血糖血脂效果好,副作用轻微。

Clinical Observation on the Effect of Acarbose Combined with Glimepiride for the Treatment of Newly Diagnosed Type 2 Diabetes Mellitus

[Objective] To observe the effect and side effect of acarbose （glueobay） combined with glimepiride for the treatment of type 2 diabetes mellitus （T2DM） patients. [Methods]Sixty-five patients with T2DM were treated with acarbose and glimepiride. The levels of BMI, FBS, PBS, GHbAlc, TC, TG and LDI. C were determined before treatment and 12 weeks after treatment. At the same time, side effects were observed. [Results]Twelve weeks after treatment, the levels of blood sugar and blood lipid were reduced sig nificantly. Side effects including gastrointestinal tract reaction and hypoglycemia were rare. [Conclusion]Acar- bose combined with glimepiride is effective for the treatment of patients with T2DM.