微卡辅助治疗老年初治菌阳肺结核疗效对比观察

目的观察和评价微卡辅助治疗老年初治菌阳肺结核的疗效.方法将120例老年初治菌阳肺结核病人随机分为治疗组和对照组各60例.对照组采用2HRZE/4 HR方案治疗.治疗组采用上述方案治疗的同时,加用微卡22.5μg,臀部肌内注射.每周1次,疗程2个月.然后观察痰菌阴转,肺部病灶吸收、空洞闭合等情况.结果痰菌阴转情况:1个月后治疗组46例,对照组32例,两组比较,差异有非常显著性(P＜0.01);2个月后治疗组55例,对照组43例,两组比较,差异有非常显著性(P＜0.01);3个月后治疗组60例,对照组58例,两组比较,差异无显著性.病变吸收情况:2、4个月及疗程结束后显效病例,治疗组分别为27、48、52例,对照组分别为14、32、40例,两组比较,差异均有非常显著性(P＜0.01).空洞闭合情况:2、4个月及疗程结束后空洞闭合病例,治疗组分别为11、19、21例,对照组分别为4、13、19例,两组比较,差异均有显著性(P＜0.05).结论微卡辅助治疗老年初治菌阳肺结核有显著性疗效.

Effect of Vaccae as Auxiliary Treatment for Sputum Positive Pulmonary Tuberculosis among Old People

Objective To observe the effect of Vaccae as auxiliary treatment for sputum positive pulmonary tuberculosis among old people. [Methods] 120 patients were divided into two groups, namely the case group and the control group. The control group were treated with 2HRZE/4 HR , the case group were treated with 2HRZE/4 HR combined with injection of Vaccae of 22.5 ug, once a week for a period of two month. Observation was made on the sputum negative conversion, focus absorption and cavity closure. [Results] The sputum negative conversion is as follows: 46 cases in the case group and 32 cases in the control group after 1 month, the difference was significant (P<0.01); 55 cases in the case group and 43 cases in the control group after 2 months, the difference was also significant (P<0.01); 60 cases in the case group and 58 cases in the control group after 3 months, the difference was not significant. The focus absorption was as follows: 27, 48 and 52 cases in the case group and 14, 32 and 40 cases in the control group after 2 moths, 4 months and after treatment respectively (P<0.01). Cavity closure is as follows: 11, 19 and 21 cases in the case group and 4,13 and 19 cases in the control group after 2 month, 4 months and after treatment respectively, the difference was significant (P<0.05). [Conclusion]Using Vaccae as auxiliary treatment for sputum positive pulmonary tuberculosis among old people is of significant effect.