High-dose carboplatin,cyclophosphamide, and BCNU with autologous bone marrow support: excessive hepatic toxicity

Summary Intensive doses of carboplatin, cyclophosphamide, and BCNU with autologous bone marrow support were given to four patients with advanced melanoma. Three developed clinically diagnosed, severe venoocclusive liver disease, which was fatal in two cases. The dose of carboplatin (450 mg/m²) was comparable with that used in ambulatory regimens. At the doses and schedule employed, this three-drug combination produced excessive hepatic toxicity. Caution is suggested when giving carboplatin in combination with intensive doses of other chemotherapeutic agents with known hepatotoxic potential. Supported in part by National Institutes of Health grant CA-14236-16