|
|||||
|
|
| 坐骨神经切断后脊髓神经细胞的凋亡变化 | |
| 引用本文： | 张晓,李爱冬,王廷华,彭阳. 坐骨神经切断后脊髓神经细胞的凋亡变化[J]. 中国组织工程研究与临床康复, 2003, 7(2): 202-203 |
| 作者姓名： | 张晓 李爱冬 王廷华 彭阳 |
| 作者单位： | 1. 解放军第三军医大学成都军医学院实验技术教研室,四川省成都市,610083 2. 昆明医学院神经科学研究所,云南省昆明市,650031 |
| 基金项目： | 成都军医学院院长基金资助(200012) |
| 摘 要： | 目的:研究一侧坐骨神经切断后,脊髓第7腰段的神经细胞的凋亡变化。方法:用DNA原位末端标记法。结果:在坐骨神经切断1d后脊髓后角内的神经胶质细胞开始出现凋亡,到第2天达到最大值,白质内的胶质细胞也发生凋亡;脊髓灰质后角感觉神经元的凋亡指数大于前角运动神经元的凋亡指数。结论:坐骨神经切断后的第1天脊髓神经细胞发生凋亡,传入神经元的凋亡大于传出神经元的凋亡,神经胶质细胞在细胞凋亡过程中发挥重要作用。 |
| 关 键 词： | 坐骨神经 脊髓 脱噬作用 |
| 文章编号： | 1671-5926(2003)02-0202-02 |
| 修稿时间： | 2002-09-26 |
The study on the apoptosis of nerve cells of spinal cord of rat following unilaterals sciatic nerve transection |
|
| Zhang Xiao,Li Aidong,Wang Tinghua,Peng YangZhang Xiao,U Aidong,Peng Yang. The study on the apoptosis of nerve cells of spinal cord of rat following unilaterals sciatic nerve transection[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(2): 202-203 | |
| Authors: | Zhang Xiao Li Aidong Wang Tinghua Peng YangZhang Xiao U Aidong Peng Yang |
| Affiliation: | Zhang Xiao,Li Aidong,Wang Tinghua,Peng YangZhang Xiao,U Aidong,Peng Yang,Department of experiment Technique,Chengdu Military College,Third Military Medical University,Chengdu 610083,Sichuan Province,ChinaWang Tinghua,Institute for Research on Neuroscience of Kunming Mendical College,Kunming 650031,Yunnan Province,China |
| Abstract: | AIM: To study the apoptotic nerve cells on spinal cord of the rat following unilaterals sciatic nerve transection. METHODS: Using the method of TdT mediated dUTP- fluorescein nick end labelling, to identification the apoptotic nerve cells in seventh waist segment. RESULTS: The apoptotic neuroglia cells in the in dorsal horn of spinal cord came forth after the first day of sciatic never transection and it come to maximate on second day, glial cells in the whiter matter also had occurrence apoptosis. The apoptotic index of neurons in dorsal horn of spinal cord was bigger than neurons in the front horn spinal cord. CONCLUSION: It suggest that there is an occurrence apoptosis in spinal cord following sciatic nerve axotomy with the neuroglia and neuronal cells loss on 1 day. The apoptosis of afferent neurons are bigger than the apoptosis of efferent neurons, Neuroglia cells apoptosis may play a great action in the course of apoptosis of the spinal cord. |
| Keywords: | sciatic nerves spinal cord apoptosis |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |