Sex cord-stromal tumors of the ovary |
| |
Authors: | Ikuo Konishi |
| |
Institution: | (1) Department of Gynecology and Obstetrics Faculty of Medicine, Kyoto University, Shogoin Kawahara-cho, Sakyo-ku, 606-01 Kyoto, Japan |
| |
Abstract: | The developmental relationship between granulosa and stromal cells in the fetal ovary was reviewed. The proliferation and
expression of basic fibroblast growth factor (bFGF) and luteinizing hormone receptor (LHR) of both the granulosa and theca
cells was examined in the adult ovary. Ovarian granulosa cell tumors were then studied under light and electron microscopy
and for immunohistochemical expression of bFGF and LHR. In the follicular development of the adult ovary, bFGF expression
in the granulosa cells was correlated with theca cell proliferation. In ovarian granulosa cell tumors, estrogen-producing
tumors showed a stratified or microfollicular pattern being accompanied by theca cells which had ultrastructural features
of steroid-production, and these tumor cells exhibited immunoreactivity for bFGF. In contrast, tumors with no apparent hormone-production
showed a solid or gyriform pattern without admixture of theca cells, and were negative for bFGF. LHR was expressed in both
types of tumor. Accordingly, bFGF may play an important role in association with the theca cell component in granulosa cell
tumors. |
| |
Keywords: | Sex cord-stromal tumor Granulosa cell tumor Ovary bFGF |
本文献已被 SpringerLink 等数据库收录! |
|