高血压肥胖者血浆促动脉硬化指数与心血管疾病风险的相关性研究

［摘要］目的 探讨中年肥胖者血浆促动脉硬化指数（atherogenic index of plas-ma,AIP）与心血管疾病风险的相关性。方法 随机选取高血压患者120例，根据内脏脂肪面积分为肥胖组和非肥胖组；根据Framingham风险评分将患者分为高危组、中危组和低危组。比较各组AIP、年龄、腰臀脂肪比、血压、体重指数、血糖和血脂，分析高血压肥胖患者AIP与心血管疾病风险的相关性。结果 高血压肥胖组AIP、腰臀脂肪比、收缩压、空腹血糖、总胆固醇、三酰甘油明显高于高血压非肥胖组，差异有统计学意义(P＜0.05)。中危组和高危组腰臀脂肪比、收缩压、体重指数、AIP均明显高于低危组，高危组腰臀脂肪比、收缩压、体重指数、AIP均明显高于中危组，差异有统计学意义(P＜0.05)。Spearman秩相关分析结果显示，AIP与心血管因素呈正相关（P＜0.05）。结论 高血压肥胖者患者均有明显的血脂紊乱和高AIP值以及10年心血管风险，AIP可作为患者心血管疾病风险的重要危险因素。

Correlation between plasma arteriosclerosis index and cardiovascular disease risk in obese patients with hypertension

［Abstract］Objective To investigate the association between the atherogenic index of plasma(AIP) and cardiovascular disease risk in middle-aged obese individuals. Methods One hundred and twenty patients with hypertension were randomly selected and divided into obese group and non-obese group according to visceral fat area. Patients were divided into high-risk group, medium risk group and low risk group according to Framingham Risk Score. AIP, age, waist-hip fat ratio, blood pressure, body mass index, blood sugar and blood lipids in each group were compared, and the correlation between AIP and cardiovascular disease risk in hypertensive obese patients was analyzed. Results AIP, waist-hip fat ratio, systolic blood pressure, fasting blood glucose, total cholesterol and triglyceride were significantly higher in the obese group than in the non-obese group(P＜0.05). Waist-hip fat ratio, systolic blood pressure, bady mass index and AIP in the middle risk group and the high-risk group were significantly higher than those in the low risk group, and the waist-hip fat ratio, systolic blood pressure, bady mass index and AIP in the high-risk group were significantly higher than those in the middle risk group(P＜0.05). Spearman correlation analysis showed that AIP was positively correlated with cardiovascular factors(P＜0.05). Conclusion All patients with hypertension and obesity have significant dyslipidemia, high AIP value and 10-year cardiovascular risk, and AIP can be an important risk factor for patients with cardiovascular disease.