| 焦亚硫酸钠与盐酸-L-半胱氨酸在延缓抗坏血酸注射液变色中的作用 |
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| 引用本文： | 程志鹏,殷恭宽.焦亚硫酸钠与盐酸-L-半胱氨酸在延缓抗坏血酸注射液变色中的作用[J].四川大学学报(医学版),1988(1). |
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| 作者姓名： | 程志鹏 殷恭宽 |
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| 作者单位： | 华西医科大学物理化学教研室
(程志鹏)，华西医科大学物理化学教研室(殷恭宽) |
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| 摘 要： | 本文探讨了焦亚硫酸钠与盐酸-L-半胱氨酸这两种稳定剂在延缓抗坏血酸注射液变色中的作用。盐酸-L-半胱氨酸能延缓2-酮-L-古洛糖酸的降解速率,也能与丙酮醛发生化学反应,延缓丙酮醛的变色速率;焦亚硫酸钠可能改变了丙酮醛的聚合方式而延缓丙酮醛的变色速率。从而在一定程度上解释了这两种稳定剂延缓抗坏血酸注射液变色的原因。
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| 关 键 词： | 焦亚硫酸钠 盐酸-L-半胱氨酸 抗坏血酸注射液 2-酮-L-古洛糖酸 丙酮醛 |
ROLES OF SODIUM PYROSULFITE AND L-CYSTEINE HYDROCHLORIDE IN RETARDING DISCOLORATION OF ASCORBIC ACID INJECTION |
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| Cheng Zhipeng,Yin Gongkuan.ROLES OF SODIUM PYROSULFITE AND L-CYSTEINE HYDROCHLORIDE IN RETARDING DISCOLORATION OF ASCORBIC ACID INJECTION[J].Journal of West China University of Medical Sciences,1988(1). |
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| Authors: | Cheng Zhipeng Yin Gongkuan |
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| Institution: | Cheng Zhipeng;Yin Gongkuan Department of Physical Chemistry |
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| Abstract: | The roles of two stabilizers, sodiumpyrosulfite and L-cysteine hydrochloride inratarding discoloration of ascorbic acid in-jection have been studied. It was found that,L-cysteine hydrochloride retarded the deg-radation rate of 2-keto-L-gulonic acid; L-cysteine hydrochloride also retarded thediscoloration rate of methylglyoxal solutionvia chemical reaction between L-cysteinehydrochloride and methylglyoxal; sodiumpyrosulfite retarded the discoloration rateof methylglyoxal solution probably due tochanging the way of polymerization ofmethylglyoxal. To a certain extent, theseresults could explain why the two stabili-zers could retard the discoloration rate ofascorbic acid injection. |
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| Keywords: | Sodium pyrosulfite L-cysteine hydrochioride Ascorbic acid injection 2-keto-L-gulonic acid Methylglyoxal |
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