Postural sensory correlates of freezing of gait in Parkinson's disease |
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| Affiliation: | 1. Department of Neurology, CHA Bundang Medical Center, CHA University, Seongnam, South Korea;2. Center for Robotics Research, Korea Institute of Science and Technology, Seoul, South Korea;3. Department of Otolaryngology, Head and Neck Surgery, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea;4. Department of Neurology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea;5. Neuroscience Center, Samsung Medical Center, Seoul, South Korea;1. Department of Physical Therapy & Athletic Training, Center for Neurorehabilitation, Boston University, Boston, MA, USA;2. Department of Physical Therapy, University of New England, Portland, ME, USA;3. Program in Physical Therapy, Washington University School of Medicine, St. Louis, MO, USA;4. Department of Physical Therapy, School of Health Professions, Samford University, Birmingham, AL, USA;5. Department of Physical Therapy, University of Utah, SLC, UT, USA;6. Department of Family and Preventative Medicine, Rocky Mountain Center for Occupational and Environmental Health, University of Utah, SLC, UT, USA;1. Department of Neurology, Seoul National University Hospital, College of Medicine, Seoul, Republic of Korea;2. Aerospace Medical Group, Air Force Education and Training Command, Jinju, Republic of Korea;3. Department of Neurology, Kyung Hee University Hospital, Seoul, Republic of Korea;4. Department of Neurosurgery, Seoul National University Hospital, College of Medicine, Seoul, Republic of Korea;1. The Norwegian Centre for Movement Disorders, Stavanger University Hospital, P.O. Box 8100, N-4068 Stavanger, Norway;2. Department of Neurology, Stavanger University Hospital, P.O. Box 8100, N-4068 Stavanger, Norway;3. Center for Clinical Research, Haukeland University Hospital, P.O. Box 1400, N-5021 Bergen, Norway;1. Institute of Epidemiology, Visegradska 26a, Faculty of Medicine, University of Belgrade, Serbia;2. Clinic of Neurology, Dr. Subotica 6, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Serbia;1. KU Leuven, Department of Rehabilitation Sciences, Heverlee, Belgium;2. Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands;3. Hasselt University, Rehabilitation Sciences and Physiotherapy, Hasselt, Belgium;4. Department of Neurology, UZ Leuven, Leuven, Belgium;1. Department of Neurology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China;2. Department of Neurology, Ningbo No.2 Hospital, Ningbo, China |
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| Abstract: | ![]()
IntroductionTo elucidate the unique patterns of postural sensory deficits contributing to freezing of gait (FOG) in patients with Parkinson's disease (PD) and to identify postural sensory modalities that correlate with FOG severity.MethodsTwenty-five PD patients with FOG, 22 PD patients without FOG, and 26 age-matched controls were evaluated using a sensory organization test and clinical measures including the Unified Parkinson's Disease Rating Scale motor score, Montreal Cognitive Assessment, Frontal Assessment Battery, Activities-specific Balance Confidence, Beck Anxiety Inventory, Beck Depression Inventory, and Berg Balance Scale. Multivariable logistic regression analysis was performed for posturographic parameters and possible confounders to determine postural sensory contributors to FOG. We also correlated FOG severity, measured using a New Freezing of Gait Questionnaire, with posturographic parameters.ResultsPD patients with FOG showed worse postural sensory processing compared with those without FOG. In particular, the inability to use the vestibular information (odds ratio [OR] 1.447; 95% confidential interval [CI]: 1.120, 1.869) and poor control over the perturbed somatosensory inputs (OR 2.904; 95% CI: 1.028, 8.202) significantly contributed to FOG. Among PD patients with FOG, FOG severity was correlated with higher reliance on visual information (ρ = −0.432, p = 0.039).ConclusionsPostural sensory deficits involving specific sensory modalities are strongly associated with FOG. Quantitative measurement of postural sensory deficits in PD patients with FOG may provide a better understanding of pathomechanisms of FOG and increase the efficacy of sensory cueing strategies for alleviating FOG, by more accurately identifying suitable patients for rehabilitative therapies. |
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| Keywords: | Parkinson's disease Freezing of gait Postural sensory deficits Vestibular impairment |
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