中国现阶段老年期痴呆患病率的Meta分析

目的]评价我国现阶段60岁及以上老年人的痴呆患病率。方法]检索2000～2009年相关数据库及其他网络资源的相关资料,对10个研究应用MetaAnalystBeta3.13软件对其进行Meta分析,选用随机效应模型合并效应量。结果]纳入患病人数累计1055人,调查人口数累计23787人。资料存在无实质性的异质性(I2=49.2%);模型有统计学意义(q=0.996,P=0.000);痴呆患病率的合并值为4.2%(95%CI为3.0%～5.8%)(P=0.000﹤0.01),并得出不同性别、年龄段、文化程度以及婚姻状况等各亚组的患病率。结论]60岁以上老年人痴呆的患病率约为4.2%,而且各亚组患病率不同。

META-ANALYSIS OF EVALUATION OF CURRENT PREVALENCE OF DEMENTIA IN ELDERLY IN CHINA

Objective]To study the prevalence and major subtypes of dementia among the population aged 60 year-old and older in China from 2000 to 2009.Methods]Epidemiological investigations on dementia in China published in journals covering the period from 2000 to 2009 were identified by using CBMDISK,Chongqing VIP database,CHKI database and so on.The random effects model of the meta-Analysis was employed according to Meta Analyst Beta 3.13 for homogeneity.Results]There were ten studies selected by assessing papers’ quality.The selects added up to 1055,the total investigation population was 23 787.It was considered that the homogeneity of the references was moderate after testing of heterogeneity(I2 = 49.2%).The model of the meta-analysis had statistical significance(q = 0.996,P = 0.000).The pooled prevalence was 4.2%(P = 0.000﹤0.01)and the 95% confidence interval was from 3.0% to 5.8%.The prevalence was analyzed according to sex,age,education and marriage.Conclusion]AD and VD were the two major subtypes of dementia in China.The prevalence of elderly population over 60 years about dementia was 4.2%,and it was significant difference between sex,age,education level and marriage.