血清前S1抗原检测在乙型肝炎病毒感染者中的临床意义

[目的]分析探究血清前S1抗原检测在乙型肝炎病毒感染者临床意义。[方法]对某院2009年6月～2010年12月收治的726例HBV感染者的血清标本中的血清标志物及血清前S1抗原采用双抗体夹心酶联免疫法(ELISA)进行检测。[结果]HBeAg(+)的322例血清标本中,PreS1Ag(+)的检出率为83.54%(269/322),HBeAg(-)的404例血清标本中,PreS1Ag(+)的检出率为26.48%(107/404)。PreS1Ag与HBV-DNA的符合率为82.92%(602/726)。[结论]PreS1Ag检测可作为HBV感染和复制的诊断试验,在临床上判断乙型肝炎病毒感染患者的病情转化、疗效及预后都有重要的作用。

THE CLINICAL SIGNIFICANCE OF THE DETECTION FOR SERUM PRE-S1 ANTIGEN IN HEPATITIS B VIRUS INFECTION

[Objective]To explore the clinical significance of the detection for serum pre-S1 antigen in hepatitis B virus infection.[Methods]The serum samples of serum markers and serum pre-S1 antigen by double antibody sandwich enzyme-linked immunosorbent assay(ELISA)in 726 cases of HBV infection from June 2009 to December 2010 were collected and taken for detection.[Results]In the HBeAg(+)of 322 serum samples,PreS1Ag(+)detection rate was 83.54%(269/322),HBeAg(-)of 404 serum samples,and PreS1Ag(+)detection rate was 26.48%(107/404).PreS1Ag compliance with HBV-DNA was 82.92%(602/726).[Conclusion]PreS1Ag detection can set as the diagnostic tests for HBV infection and replication.It has an important role in determining the transformation of clinical condition of patients with hepatitis B virus infection,the efficacy and prognosis.