椎间盘退变模型的研究进展

目前国内外关于椎间盘退变的病因和发病机制尚无定论,构建能模拟人退变椎间盘的动物模型是研究的关键。常用于研究椎间盘退行性疾病的模型可分为体内、体外模型。目前已成功建立的椎间盘动物模型均具有一定的局限性,尚无公认的能够完全模拟人类椎间盘退变的标准模型。随着大型动物与灵长类动物模型的建立,动物椎间盘退变模型与人类椎间盘退变之间的相关性和可比性逐渐明确,其在椎间盘退变疾病的研究中具有广阔的前景。

Research Advances in Intervertebal Disc Degeneration Models

The etiology and pathogenesis of intervertebal disc degeneration is still not clear at home and abroad,and an animal model which can simulate the human intervertebral disc degeneration is the key to the study.Presently,the intervertebral disc degeneration model can be divided into two kinds:in vivo and ex vivo models.The established intervertebral disc animal models have certain limitations,and there is no acknowledged standard model which can completely simulate human intervertebral disc degeneration.With the large animal and primate animal models established,the relativity and comparability between animal and human intervertebal disc degeneration are gradually clear,and the animal models have broad prospects in the research.