Switch from antagonist to agonist after addition of a DOTA chelator to a somatostatin analog |
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| Authors: | Jean Claude Reubi Judit Erchegyi Renzo Cescato Beatrice Waser Jean E. Rivier |
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| Affiliation: | (1) Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Berne, PO Box 62, Murtenstrasse 31, 3010 Berne, Switzerland;(2) The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, CA 92037, USA |
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| Abstract: | Purpose Peptide receptor targeting has become an increasingly attractive method to target tumors diagnostically and radiotherapeutically. Peptides linked to a variety of chelators have been developed for this purpose. They have, however, rarely been tested for their agonistic or antagonistic properties. We report here on a somatostatin antagonist that switched to an agonist upon coupling to a DOTA chelator. |
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