| 吡格列酮对实验性缺血再灌注大鼠脑组织细胞间黏附分子-1mRNA表达的影响 |
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| 引用本文： | 田朝晖,刘尊敬.吡格列酮对实验性缺血再灌注大鼠脑组织细胞间黏附分子-1mRNA表达的影响[J].中华行为医学与脑科学杂志,2009,18(7). |
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| 作者姓名： | 田朝晖 刘尊敬 |
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| 作者单位： | 中日友好医院神经内科,北京,100029 |
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| 摘 要： | 目的 观察PPARγ激活剂吡咯列酮对实验性缺血再灌注脑组织区细胞间黏附分子-1(ICAM-1)mRNA表达的影响.方法 健康成年雄性SD大鼠,随机分4组,每组6只,分别为假手术组、生理盐水组、小剂量吡格列酮组、大剂量吡格列酮组.线栓法制备大脑中动脉闭塞动物模型.术前3d分别给予盐酸吡咯列酮,每日1次灌胃给药,小剂量组为10mg·kg-1·d-1,大剂量组为15mg·kg-1·d-1.以缺血后24 h作为观察时间点,RT-PCR测定缺血脑组织mRNA表达.结果 小剂量吡格列酮组ICAM-1 mRNA表达(0.571±0.032)和大剂量吡格列酮组ICAM-1mRNA表达(0.396±0.024)均较生理盐水干预组(0.847±0.028)低(P<0.05).结论 PPARγ激活剂吡咯列酮可下调缺血脑组织ICAM-1mRNA的表达.
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| 关 键 词： | 过氧化小体增殖剂激活型受体γ 脑缺血再灌注 细胞间黏附分子-1 |
The effects of pioglitazone on the expression of ICAM-1 mRNA in the ischemia-reperfusion brain tissues in SD rats |
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| Authors: | TIAN Zhao-hui LIU Zun-jing |
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| Abstract: | Objective To study the effects of peroxisome prolifterator-activated receptor gamma (PPARγ) agonist on the expression of ICAM-1 mRNA in the ischemia-reperfusion brain tissues. Methods Adult male SD rats were randomly divided into: sham-operation + normal saline group (NS,n = 6 ), ischemia-reperfusion tion. The expression of ICAM-1mRNA was measured by RT-PCR at 24 h after ischemia. Results The expression of ICAM-1 mRNA of the low-dose PGZ group (0.571±0.032) and the high-dose PGZ group (0. 396±0.024)were significantly reduced compared with that of the I/R + NS group (0.847±0. 028 ) (P<0.05).Conclusion PPARγ agonists can downregulate the the expression of ICAM-1mRNA in the ischemia brain tissue. |
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| Keywords: | Peroxisome prolifterator-activated receptor γ Cerebral ischemia-reperfusion Intercellu-lar adhesion molecule-1 |
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