Multidomain lifestyle intervention benefits a large elderly population at risk for cognitive decline and dementia regardless of baseline characteristics: The FINGER trial |
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| Authors: | Anna Rosenberg Tiia Ngandu Minna Rusanen Riitta Antikainen Lars Bäckman Satu Havulinna Tuomo Hänninen Tiina Laatikainen Jenni Lehtisalo Esko Levälahti Jaana Lindström Teemu Paajanen Markku Peltonen Hilkka Soininen Anna Stigsdotter-Neely Timo Strandberg Jaakko Tuomilehto Alina Solomon Miia Kivipelto |
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| Affiliation: | 1. Institute of Clinical Medicine, Department of Neurology, University of Eastern Finland, Kuopio, Finland;2. Department of Public Health Solutions, Chronic Disease Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland;3. Division of Clinical Geriatrics, Center for Alzheimer Research, NVS, Karolinska Institutet, Stockholm, Sweden;4. Department of Neurology, North Karelia Central Hospital, Joensuu, Finland;5. Center for Life Course Health Research/Geriatrics, University of Oulu, Oulu, Finland;6. Medical Research Center Oulu, Oulu University Hospital, Oulu, Finland;g. Oulu City Hospital, Oulu, Finland;h. Aging Research Center, Karolinska Institutet-Stockholm University, Stockholm, Sweden;i. Aging, Disability and Functioning Unit, National Institute for Health and Welfare, Helsinki, Finland;j. Department of Neurology, Kuopio University Hospital, Kuopio, Finland;k. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;l. Joint municipal authority for North Karelia Social and Health services, Joensuu, Finland;m. Department of Public Health, University of Helsinki, Helsinki, Finland;n. Finnish Institute of Occupational Health, Helsinki, Finland;o. Neurocenter, Neurology, Kuopio University Hospital, Kuopio, Finland;p. Department of Psychology, Umeå University, Umeå, Sweden;q. Department of Social and Psychological Sciences, Karlstad University, Karlstad, Sweden;r. University of Helsinki, Helsinki University Hospital, Helsinki, Finland;s. South Ostrobothnia Central Hospital, Seinäjoki, Finland;t. Stockholms Sjukhem, Research & Development Unit, Stockholm, Sweden |
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| Abstract: | ![]()
IntroductionThe 2-year Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain lifestyle intervention trial (NCT01041989) demonstrated beneficial effects on cognition. We investigated whether sociodemographics, socioeconomic status, baseline cognition, or cardiovascular factors influenced intervention effects on cognition.MethodsThe FINGER recruited 1260 people from the general Finnish population (60–77 years, at risk for dementia). Participants were randomized 1:1 to multidomain intervention (diet, exercise, cognition, and vascular risk management) and regular health advice. Primary outcome was change in cognition (Neuropsychological Test Battery z-score). Prespecified analyses to investigate whether participants' characteristics modified response to intervention were carried out using mixed-model repeated-measures analyses.ResultsSociodemographics (sex, age, and education), socioeconomic status (income), cognition (Mini–Mental State Examination), cardiovascular factors (body mass index, blood pressure, cholesterol, fasting glucose, and overall cardiovascular risk), and cardiovascular comorbidity did not modify response to intervention (P-values for interaction > .05).ConclusionsThe FINGER intervention was beneficial regardless of participants' characteristics and can thus be implemented in a large elderly population at increased risk for dementia. |
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| Keywords: | Prevention Cognitive impairment Dementia Alzheimer's disease Multidomain Lifestyle Intervention Randomized controlled trial |
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