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Synthesis and radioreceptor binding activity of N-0437, a new,extremely potent and selective D2 dopamine receptor agonist
Authors:A. S. Horn  P. Tepper  J. Van Der Weide  M. Watanabe  D. Grigoriadis  P. Seeman
Affiliation:1. Department of Pharmacy, University of Groningen, Ant. Deusinglaan 2, 9713, AW Groningen, The Netherlands
2. Department of Pharmacology, University of Toronto, M5S1A8, Toronto, Canada
Abstract:The synthesis of a new, potent and selective D2 dopamine receptor agonist, N-0437, of the 2-aminotetralin group is described. The results of a radioreceptor binding assay using a homogenate of porcine anterior pituitary as a tissue source for D2 dopamine receptors and3H-spiperone as radioligand demonstrate that this compound is one of the most potent compounds so far evaluated in this test system.
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