A Human Monoclonal Antibody to rhG |
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| Authors: | Steven K.H. Foung Judy Blunt Susan Perkins Linda Winn and F. Carl Grumet |
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| Affiliation: | Department of Pathology, Stanford University Medical Center, Calif., USA;Gene Labs, Inc., San Carlos, Calif., USA |
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| Abstract: | Hybridomas secreting a human monoclonal IgG1 antibody against a variant of the rhG antigen were produced from B lymphocytes of an Rh-negative donor with serum antibodies to D and G [correction of C] antigens. The antibody reacts by indirect hemagglutination with nearly all C- or D-positive cells, confirming the strong association in the expression of G with D or C antigens. The lack of antibody reactivity to C-negative Du cells suggests a particular epitope on the D complex associated with the G antigen. |
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