组织因子和活化的血小板在肺癌中的研究进展

浸润、转移及血管生成是肺癌发生、发展必要的条件,也是影响疗效和预后的主要因素。肺癌患者常伴有组织因子高表达,同时诱发血小板活化,研究发现组织因子和活化的血小板均与肺癌的浸润、转移及血管生成有着密切的关系,且活化血小板的表达物CD62p介导肺癌细胞与血小板及血管内皮细胞黏附起着极其重要的作用,它们共同推动肺癌病程的进展。在此重点讨论组织因子及活化的血小板在肺癌中的表达及参与肺癌恶性生物学行为的作用机制。

Recent Research Progress of Tissue Factors and Ativated Platelet in Lung Cancer

The invasion,metastasis and angiogenesis are not only the necessary conditions of lung cancer genesis and development,but also the main factors affecting the curative effect and prognosis.Patients with lung cancer are often accompanied with high expression of tissue factors and evoked platelet activation.It is found in researches that tissue factors and activated platelets have close relations with lung cancer invasion,metastasis and angiogenesis.Furthermore,the expressed proteins of activating platelet,CD62p,plays an important role in mediating adhesion between lung cancer cells and platelet,together with endothelial cells,which propel the development of lung cancer progression.Here is mainly to discuss the tissue factors and activated platelets expression in lung cancer and the biological behaviors mechanism involved in malignant lung cancer.