人格障碍遗传度双生子研究

目的利用双生子人群估计人格障碍的遗传度.方法采用人格障碍诊断问卷第4版（PDQ-4）作为筛查工具,在知情同意的基础上,对青岛市20～70岁的成人双生子进行问卷调查.其中已知卵性鉴定结果的双生子共324对,对其中性别相同的242对双生子进行结构方程模型拟合,计算人格障碍的遗传度.结果人格障碍总评分遗传度为68.26%（60.26～74.78）,A组评分遗传度为59.00%（49.22～67.17）,B组评分遗传度为64.99%（56.24～72.16）,C组评分遗传度为63.66%（54.72～71.02）.分裂型、自恋型和依赖型有显著的遗传效应,遗传度分别为49.96%（37.94～60.14）、52.89%（41.85～62.24）和68.87%（60.80～75.40）.戏剧型不受遗传因素作用,共同环境效应显著,占总变异方差的54.08%（44.50～62.43）.结论人格障碍主要受遗传因素决定,这些结果将会对人格障碍的进一步研究提供依据.

A twin study of personality disorder heritability

Objective To calculate heritabilities of personality disorders(PDs) in twin population. Methods Based on informed consent, we used Personality Diagnostic Questionnaire(fourth-version) as our screening tool to study the adult twins(aged 20-70 years) in Qingdao city. There were 324 twin pairs whose zygosity had been determined. Structural equation modeling was used to estimate the heritabilities by 242 same-sex twin pairs. Results The best-fitting models yielded a heritability of 68.26%( 60.26- 74.78) of overall PDs, 59.00%( 49.22- 67.17) of cluster A, 64.99%( 56.24- 72.16) of cluster B, and 63.66%( 54.72- 71.02) of cluster C. There were significant genetic effects for schizotypal, narcissistic and dependent, explaining 49.96%( 37.94- 60.14), 52.89%( 41.85- 62.24) and 68.87%( 60.80- 75.40) of the variance respectively. No genetic effects were found on Histrionic, but common environmental effect accounted for 54.08%( 44.50- 62.43) of the total variances. Conclusion PD was mainly determined by genetic factor. These findings may provide evidence for future research on PD.