裸鼠乳腺癌的超声研究

目的研究裸鼠乳腺癌的超声表现特点,为人乳腺癌的超声诊断提供有效依据。方法采用MCF-7细胞株建立裸鼠乳腺癌瘤模型,待原位移植后第23天用超声观察其图像的特点,并与人乳腺癌的特点进行对比分析。结果裸鼠乳腺癌平均大小7.4mm×5.6mm;椭圆形,内部低回声,分布均匀,境界清晰和尚清晰;并与人乳腺癌之特点有许多不同。结论裸鼠乳腺癌的生长仅23天,而人乳腺癌的生长数月至数年,两者图像之特点有许多不同。对<10mm或很早的原位癌超声缺乏特征性指标而易误诊为良性肿瘤。

Ultrasound Study of Breast Cancer in Nude Mice

Objective To study the ultrasonic characteristics of breast cancer in nude mice and provide effective basis in ultrasonic diagnosis of human breast cancer.Methods The breast cancer model was established in nude mice by MCF-7 cell strain;the ultrasound image characteristics of transplant tumor were observed on the 23rdday after orthotopic transplantation and compared with the characteristics of the human breast cancer.Results The average size of transplant tumor was 7.4 mm × 5.6 mm;the ultrasound image showed the characteristics of oval,internal hypoechoic,evener distribution,clear or general clear boundary,which had many differences compared with the human breast cancer.Conclusions The growth of breast cancer in nude mice is only 23 days,while the growth of human breast cancer is a few months to several years.The ultrasonic characteristics are different between nude mice and human.The carcinoma in situ with size < 10 mm or at the early stage is easily misdiagnosis to benign due to lack of typical ultrasonic characteristics.