海藻酸钠敷料止血性能的实验研究

目的:研究一种功能型敷料:海藻酸敷料(本项目已申请国家专利,并初审合格,申请号:201010213206.4)的止血性能。方法:取新西兰兔5只,在背部两侧对称性剪6个直径1cm的圆形创口,分别用与创面大小相当的海藻酸敷料和云南白药创口贴止血,观察与创面的粘附情况,记录出血时间;止血停止后,将海藻酸敷料和云南白药创口贴放入预先配制好的氰化高铁血红蛋白检测试剂中仔细清洗,用分光光度计在540nm波长处光度比色,测出的Hb光度吸收值表示出血量。结果:海藻酸敷料与创面粘附较好,海藻酸敷料组、云南白药创口贴组的出血时间分别为(84.63±19.1)s、(169.33±22.6)s,Hb光度吸收值分别为(1.069±0.4)、(1.735±0.733),经统计学分析,两组数据都有显著性差异(P0.01),海藻酸敷料组明显优于云南白药创口贴组。结论:海藻酸敷料具有较好的止血性能。

Experimental study of the hemostatic properties of sodium alginate dressing

Objective: To study a functional dressing: alginate dressing(this project has applied for national patents,and qualified candidates to apply for: 201010213206.4).Hemostatic properties.Methods: New Zealand rabbits 5,6 1cm in diameter circular wound in the back on both sides of the symmetry cut,respectively,equivalent to the wound the size of alginate dressings and Yunnan Baiyao bandage to stop bleeding,observation and wound adhesion,records bleeding time;stop the bleeding stopped,the alginate dressing and Yunnan Baiyao bandage into the pre-prepared from methemoglobin cyanide detection reagent be carefully cleaned with a spectrophotometer at 540nm wavelength photometric colorimetric measure the Hb luminosity absorption values expressed blood.Conclusion: Alginate dressings with good hemostatic properties.