舒风宁痛胶囊药效学研究

目的:研究舒风宁痛胶囊对痛风症的药理作用.方法:以足跖注射1％的角叉菜胶造成大鼠足跖肿胀模型,观察舒风宁痛胶囊0.06,0.018,0.006 g·kg-1 ig 7,15 d对足跖厚度的影响.饲料中加入5％的氧嗪酸钾和1％的尿酸,15 g/只,限量喂食24 d造成大鼠痛风性肾病模型,观测给药11,24 d血尿酸水平.采用热板法和扭体反应测定给药7,15d小鼠的痛阈,小鼠剂量均为0.1,0.03,0.01 g·kg-1.用酵母诱导出小鼠高尿酸血症,测定给药15 d血尿酸水平.结果:舒风宁痛胶囊高量0.06,0.018 g·kg-1用药7～15 d后可显著对抗角叉菜胶诱发的大鼠足跖炎性肿胀.0.1,0.03 g·kg-1对小鼠具有显著的镇痛作用.舒风宁痛胶囊0.06,0.018 g·kg-1 11,24 d可显著对抗氧嗪酸钾诱发的大鼠高尿酸血症的血尿酸的水平,0.1,0.03 g·kg-1用药15 d可显著对抗酵母膏诱发的小鼠高尿酸血症的血尿酸的水平.结论:舒风宁痛胶囊对痛风有良好的治疗作用.

Pharmacodynamics Study on Shufeng Ningtong Capsule

Objective: To study pharmacological effect of Shufeng Ningtong capsule (SNC) on gout. Method: Rat paw edema model was induced by injection of 1% carrageenan in footpad. SNC of 0.06, 0.018, 0.006 g·kg^-1 (ig 7, 15 d) was given to the model rats, and effect on paw thickness was investigated and analyzed. Gouty nephropathy model in rat was established by adding 5% oxonic acid potassium and uric acid 1% (15 g each rat) in the limited feed for 24 d. Mouse model of hyperuricemia was induced by yeast. Blood uric acid level was monitored at 11 d and 24 d. Pain threshold at 7, 15 d in mice was determined by using hot plate method and writhing reaction.SNC dose in mice were 0.1, 0.03, 0.01 g·kg^-1. Result: Rat footpad swelling induced by carrageenan was antagonized by SNC (0.06, 0.018 g·kg^-1) after 7-15 d. SNC (0.1, 0.03 g·kg^-1) showed significant analgesic effect in mice. SNC (0.06, 0.018 g·kg^-1, 11, 24 d) could significantly inhibit oxonic acid potassium induced rat hyperuricemia uric acid level. SNC (0.1, 0.03 g·kg^-1, 15 d) could significantly decrease hyperuricemia uric acid in mouse model induced by yeast. Conclusion: SNC has good therapeutic effect on gout.