| Effect
of Batroxobin on Expression of C-Jun in Left Temporal Ischemic Rats with Spatial Learning
and Memory Disorder |
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| 作者姓名： | 吴卫平 匡培根 姜树军 扬炯炯 隋南 匡培梓 张小澍 |
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| 作者单位： | Neurotransmitter Research Laboratory Department of Neurology，Chinese PLA General Hospital，Postgraduate Military Medical School，Beijing 100853，Neurotransmitter Research Laboratory，Department of Neurology，Chinese PLA General Hospital，Postgraduate Military Medical School，Beijing 100853，Neurotransmitter Research Laboratory，Department of Neurology，Chinese PLA General Hospital，Postgraduate Military Medical School，Beijing 100853，Institute of Psychology，Chinese Academy of Sciences，Beijing 100101，Institute of Psychology，Chinese Academy of Sciences，Beijing 100101，Institute of Psychology，Chinese Academy of Sciences，Beijing 100101，PLA 261 Hospital，Beijing 100094 |
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| 摘 要： | The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memorydisorder was investigated by means of Morri's water maze and immunohistochemistry methods.Theresults showed that the mean reaction time and distance of temporal ischemic rats for searching a goalwere significantly longer than those of sham-operated rats,and at the same time c-Jun expression ofleft temporal ischemic region was significantly increased.However,the mean reaction time anddistance of Batroxobin-treated rats were shorter and they used normal strategies more often andearlier than those of ischemic rats.The number of c-Jun immune reactive cells of Batroxobin-treatedrats was also less than that of ischemic group.In conclusion,Batroxobin can improve spatial memorydisorder in temporal ischemic rats,and the down-regulation of the expression of c-Jun is probablyrelated to the neuroprotective mechanism.
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Effect of batroxobin on expression of c-Jun in left temporal ischemic rats with spatial learning and memory disorder. |
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| W Wu,P Kuang,S Jiang,J Yang,N Sui,A Chen,P Kuang,X Zhang.Effect
of Batroxobin on Expression of C-Jun in Left Temporal Ischemic Rats with Spatial Learning
and Memory Disorder[J].Journal of Traditional Chinese Medicine,2000,20(2):147-151. |
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| Authors: | W Wu P Kuang S Jiang J Yang N Sui A Chen P Kuang X Zhang |
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| Institution: | Department of Neurology, Chinese PLA General Hospital, Postgraduate Military Medical School, Beijing. |
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| Abstract: | The effect of Batroxobin on expression of c-Jun in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemistry methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats, and at the same time c-Jun expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of c-Jun immune reactive cells of Batroxobin-treated rats was also less than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder in temporal ischemic rats, and the down-regulation of the expression of c-Jun is probably related to the neuroprotective mechanism. |
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