糖尿病患者医院感染危险因素的荟萃分析

目的 通过对国内有关糖尿病危险因素的病例对照研究结果进行荟萃分析（meta analysis），综合评价几个常见危险因素的作用，以期从中找出糖尿病医院感染危险因素及其防治对策。方法以中国生物医学文献数据库（CBMdisc）和中国学术期刊全文数据库（CHKD），检索1997～2004年国内已发表的相关文献，选择符合标准的文献进行荟萃分析。结果经过分析年龄、病程、住院天数、血糖控制情况、有创检查、抗生素应用的因素差异在统计学上有显著性；性别、并发症因素差异在统计学上无显著性。结论年龄低、病程短、住院天数少、血糖控制理想、无有创检查和用抗生素的患者，发生医院感染的危险性低；性别、是否有并发症不是发生医院感染的危险因素；从国内现有的临床研究文献看，水平有待提高，因此有必要开展更多设计实施良好的临床随机对照试验，使将来的系统评估能真正有证可循，以更好地为临床解决问题。

Risk Factors of Nosocomial Infection on Diabetes: A Meta Analysis

OBJECTIVE To provide evidence for decision on the risk factors of nosocomial infection in diabetes. METHODS To search CMBdisc and CHKD supplemented by information from trial registers, 8 epidemiological studies on the risk factors of nosocomial infection on diabetes from 1997 to 2004 were analyzed synthetically by meta analysis. RESULTS Through analysis age, course, hospitalization days, blood sugar, wound check, and antibiotics utilization were of the significant statistical difference. Risk, sex and complication were of no significant statistical difference. CONCLUSIONS The factors of nosocomial infection on diabetes are age, course, hospitalization days, blood sugar, wound check, and antibiotics utilization. But this meta analysis only included domestic papers. There need enough evidence to support the result and may justify further research.