番茄红素对甲基戊基亚硝胺在大鼠中致癌性的影响

目的：观察番茄红素对甲基戊基亚硝胺（MANA）致癌性的影响。方法：随机将Wistar大鼠分为3组：MANA组（M）、MANA＋番茄酱组（M＋LP）和对照组（C）。实验期为26周。观察大鼠食管和胃粘膜病理变化，同时检测血清活性氧单位（ROS unit）、超氧化物歧化酶（SOD）、丙二醛（MDA）以及全血谷胱甘肽过氧化物酶（GSH－Px）水平。结果：M组和M＋LP组大鼠食管和前胃均发生癌前病变，而M＋LP组大鼠癌前病变发生率低于M组；M＋LP组大鼠血中ROSunit、SOD、GSH-Px活性较M组高，MDA含量较M组低。结论：番茄红素具有抑制MANA致癌的作用，其机制可能与抑制脂质过氧化反应有关。

EFFECT OF LYCOPENE ON CARCINOGENICITY OF N METHYL N AMYLNITROSAMINE IN WISTAR RATS

Purpose: To study the effects of lycopene on the carcinogenicity of N methyl N amylnitrosamine(MANA) in Wistar rats. Methods: The rats were randomly divided into three groups: simple MANA (M), MANA plus tomato jam (M+LP) and control(C) groups. The experiment lasted 26 weeks. Histological \{examination\} was done and the levels of ROS unit, SOD, GSH Px and MDA in the blood were determined. Results: There were precancerous lesions of esophagus or forestomach in the M and M+LP groups. The incidence of precancerous lesions in the M+LP group was decreased, and the levels of ROS unit, SOD, GSH Px in the blood were higher, but the content of MDA was decreased. Conclusion: Lycopene may have an inhibitory effect on the carcinogenicity of MANA. The effect may be due to the inhibition of lipid peroxidation.