白芍总苷联合甲氨蝶呤治疗类风湿关节炎疗效的Meta分析

目的:系统分析白芍总苷(TGP)联合甲氨蝶呤(MTX)治疗类风湿性关节炎(RA)的临床疗效。方法:计算机检索PubMed、中国知网全文数据库、中国生物医学文献数据库、万方数据库,收集关于TGP联合MTX治疗RA的随机对照试验,采用Cochrane系统评价法评价纳入研究的质量,使用RevMan5.3软件对纳入文献进行Meta分析。结果:共筛选符合要求者10项,合计患者867例,试验组484例,对照组383例。治疗4周及8周时,2组总有效率差异均无统计学意义(P>0.05);治疗12周及24周时,2组总有效率差异均有统计学意义(P<0.01)。结论:TGP联合MTX治疗RA总有效率优于单用MTX。

Meta-analysis of total glucosides paeony combined with methorexate in the treatment of rheumatoid arthritis

Objective:To analyze the clinical efficacy of total glucosides paeony ( TGP ) combined with methorexate ( MTX ) in treatment of rheumatoid arthritis. Methods:Randomized controlled trials about the effect of TGP combined with MTX on patients were collected by searching PubMed,China National Knowledge Infrastructure,China Biology Medicine disc and Wan Fang Database. The quality of included studies was assessed according to the criteria recommended Cochrane Collaboration, Meta-analysis was performed using RevMan5. 3 software. Results:Ten randomized controlled trials involving 867 patients were included,484 in experimental group, and 383 in control group. Meta-analysis results were shown that the effective rate of experimental group was better than that of control group after 12 and 24 weeks(P < 0. 01). Nevertheless,there were no statistical significance about the effective rate between experimental group and control group after 4 and 8 weeks(P >0. 05). Conclusions:TGP combined with MTX in the treatment of rheumatoid arthritis is much better than MTX alone in total effective rate.