| XAGE-1 b基因在良性前列腺增生症与前列腺癌中的表达及其意义 |
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| 引用本文： | 陈阳生,江文生,许锡荣,毕学成,钟惟德. XAGE-1 b基因在良性前列腺增生症与前列腺癌中的表达及其意义[J]. 中华实验外科杂志, 2011, 28(3). DOI: 10.3760/cma.j.issn.1001-9030.2011.03.047 |
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| 作者姓名： | 陈阳生 江文生 许锡荣 毕学成 钟惟德 |
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| 作者单位： | 1. 广东省普宁市人民医院泌尿外科,513000
2. 广州市第一人民医院泌尿外科 |
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| 摘 要： | 目的 观察XAGE-1b基因在良性前列腺增生症和前列腺癌中的表达,探讨其数值对良性前列腺增生症和前列腺癌各项指标的临床意义.方法 运用实时荧光定量聚合酶链反应(PCR)方法检测38例前列腺癌病理组织以及40例良性前列腺增生症组织XAGE-1b的基因表达水平.结果 XAGE-1b在前列腺癌组织中表达值为8.299 50±0.97116,在良性前列腺增生症组织中表达值为3.007 80±0.91600,差异有统计学意义(P＜0.05).XAGE-1b表达值随着Gleason评分、临床分期和肿瘤恶性程度升高而表达增强(P＜0.05).结论 XAGE-1b基因高表达值有助于前列腺癌的诊断和指导前列腺癌的恶性程度分期.Abstract：Objective To study the XAGE-1 b mRNA expression in prostate cancer (PCa) tissues and benign prostate hyperplasia (BPH) tissues,and explore the diagnostic values of XAGE-1 b mRNA expression level in PCa and BPH.Methods A sensitive,real-time quantitative polymerase chain reaction (PCR) assay was developed to compare the expression difference of XAGE-1b mRNA in PCa and BPH tissues,by testing 38 samples of PCa and 40 samples of BPH.Results The expression level of XAGE-1 b in PCa tissue was 8.299 50 ± 0.971 16,and 3.007 80 ± 0.916 00 in BPH tissue ( P＜0.05 ).The XAGE-1 b expression levels were increased with the increase of the Gleason score,clinical stage and malignant grade (P＜0.05).Conclusion The high expression of of XAGE-1 b mRNA can afford a reliable and helpful information for diagnosis of PCa and BPH,and PCa malignant grade.
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| 关 键 词： | 前列腺增生症 前列腺癌 诊断 |
Association of XAGE-1b gene expression levels with benign prostate hyperplasia and prostate cancer |
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| CHEN Yang-sheng,JIANG Wen-sheng,XU Xi-rong,BI Xue-cheng,ZHONG Wei-de. Association of XAGE-1b gene expression levels with benign prostate hyperplasia and prostate cancer[J]. Chinese Journal of Experimental Surgery, 2011, 28(3). DOI: 10.3760/cma.j.issn.1001-9030.2011.03.047 |
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| Authors: | CHEN Yang-sheng JIANG Wen-sheng XU Xi-rong BI Xue-cheng ZHONG Wei-de |
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| Abstract: | Objective To study the XAGE-1 b mRNA expression in prostate cancer (PCa) tissues and benign prostate hyperplasia (BPH) tissues,and explore the diagnostic values of XAGE-1 b mRNA expression level in PCa and BPH.Methods A sensitive,real-time quantitative polymerase chain reaction (PCR) assay was developed to compare the expression difference of XAGE-1b mRNA in PCa and BPH tissues,by testing 38 samples of PCa and 40 samples of BPH.Results The expression level of XAGE-1 b in PCa tissue was 8.299 50 ± 0.971 16,and 3.007 80 ± 0.916 00 in BPH tissue ( P＜0.05 ).The XAGE-1 b expression levels were increased with the increase of the Gleason score,clinical stage and malignant grade (P＜0.05).Conclusion The high expression of of XAGE-1 b mRNA can afford a reliable and helpful information for diagnosis of PCa and BPH,and PCa malignant grade. |
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| Keywords: | XAGE-1b |
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