乳腺癌和乳腺良性肿物体表傅里叶变换红外光谱研究

目的 探讨利用傅里叶变换红外(FTIR)光谱技术鉴别乳腺癌和乳腺良性肿物的可行性.方法 联合运用衰减全反射(ATR)探头与中红外光纤、FTIR光谱分析仪,测定26例乳腺癌患者和34例乳腺良性肿物患者体表的FTIR光谱,比较两组光谱各个谱带的峰位(P)、相对峰强(I)及半高宽指标(F),总结乳腺癌体表光谱的特征.结果 与乳腺良性肿物体表光谱比较,乳腺癌体表光谱中(1)蛋白质酰胺Ⅱ带P1546发生明显地红移(向低波数移动,P＜0.05);(2)与核酸相关的相对峰强11256/I1460(P＜0.05)明显升高;(3)与C-H或C-O-H的变角振动的谱带峰位P1303发生明显地红移(向低波数移动)(P＜0.05).结论 乳腺癌体表FTIR光谱与乳腺良性肿物体表的光谱比较,在蛋白质、核酸和脂类相关谱带均有明显差异.

Abstract：

Objective To explore the feasibility of superficially differentiating breast cancer from the benign fourier transform infrared ( FTIR) spectroscopy. Methods Twenty-six cases of breast cancer and 34 cases of the benign were examined superficially by FTIR spectroscopy. For each FTIR spectrum,the peak positions (P), relative intensity (I) and full width at half maximum ( F) of the band were recorded and the relative intensity ratios were calculated. Results In the group of breast cancer, both the peaks of 1546 cm-1 and 1303 cm-1 shifted toward lower wave number (P ＜0. 05), as compared to those of the benign group. The relative intensity ratio of I1256/I1460) was increased significantly (P ＜ 0. 05). Conclusion There existed many significant differences in FTIR spectra between malignant and benign breast masses.

Superficial detection of breast mass by fourier transform infrared spectroscopy: caner versus the benign

Objective To explore the feasibility of superficially differentiating breast cancer from the benign fourier transform infrared ( FTIR) spectroscopy. Methods Twenty-six cases of breast cancer and 34 cases of the benign were examined superficially by FTIR spectroscopy. For each FTIR spectrum,the peak positions (P), relative intensity (I) and full width at half maximum ( F) of the band were recorded and the relative intensity ratios were calculated. Results In the group of breast cancer, both the peaks of 1546 cm-1 and 1303 cm-1 shifted toward lower wave number (P ＜0. 05), as compared to those of the benign group. The relative intensity ratio of I1256/I1460) was increased significantly (P ＜ 0. 05). Conclusion There existed many significant differences in FTIR spectra between malignant and benign breast masses.