“The developmental and functional logic of neuronal circuits”: commentary on the Kavli Prize in Neuroscience期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

“The developmental and functional logic of neuronal circuits”: commentary on the Kavli Prize in Neuroscience

Authors:	J.C. Glover

Affiliation:	Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, PB 1103, Blindern, 0317 Oslo, Norway

Abstract:	The first Kavli Prize in Neuroscience recognizes a confluence of career achievements that together provide a fundamental understanding of how brain and spinal cord circuits are assembled during development and function in the adult. The members of the Kavli Neuroscience Prize Committee have decided to reward three scientists (Sten Grillner, Thomas Jessell, and Pasko Rakic) jointly “for discoveries on the developmental and functional logic of neuronal circuits”.

Keywords:	Grillner S Jessell TM Rakic P cerebral cortex cortical layers radial glia radial unit hypothesis neuronal migration connectivity evolution spinal cord sensorimotor circuits molecular specification of neurons locomotor central pattern generator network organization brain anatomy human monkey primate histogenesis tritiated thymidine neurogenesis spatiotemporal map last mitotic division neuronal identity &ldquo migration disorders&rdquo ocular dominance columns cytoarchitectonic ependyma proliferative unit prot-map neuronal progenitors substance P sensory transmitters sensory neurons pain opiates capsaicin acetylcholine receptors recognition molecules embryonic development hybridoma monoclonal antibodies epitopes surface molecules molecular markers commissural interneurons chemotropic floor plate axonal pathfinding nerve fiber trajectories notochord signaling gradient nuclear transcription factors dorsoventral patterning motoneuron pools anteroposterior patterning retionoic acid hox genes motoneuron diseases amyotrophic lateral sclerosis adhesion molecules sensorimotor reflex circuits sonic hedgehog shh motor control muscle spindles stretch reflex reticulospinal vestibulospinal mammalian cat fish lamprey supraspinal centers swimming locomotion anatomy electrophysiology fictive locomotion bistable membrane excitatory aminoacid NMDA receptors rhythmicity computer simulation laser scanning confocal microscopy spinal cord injury striatum goal-directed behavior informatics neuroinformatics neuromechanical model
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