非小细胞肺癌中血管内皮生长因子与树突细胞的关系

血管内皮生长因子(VEGF)是重要的肿瘤细胞生长因子之一,其可以抑制树突细胞(DC)的分化成熟,诱导成熟DC功能障碍,而DC亦可通过自分泌VEGF加重自身的功能障碍,从而介导肿瘤细胞逃逸免疫监视.因此VEGF和DC的相互关系与非小细胞肺癌(NSCLC)的分化程度、淋巴结转移、临床分期密切相关.二者关系可为临床NSCLC的治疗提供相应理论依据.

Relationship between vascular endothelial growth factor and dendritic cells in non-small cell lung cancer

Vascular endothelial growth factor( VEGF) is recognized as a key factor in tumor,which can hamper dendritic cells( DC) to mature. Thus DC can secrete VEGF to induce self-dysfunction,to induce tumor cells escaping from immune surveillance. The relationship between VEGF and the DC is closely related with the differentiation,clinical stages and lymph node metastasis in non-small-cell lung carcinoma(NSCLC). It can pro-vide appropriate theoretical basis for clinical treatment of NSCLC.