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| 调节性T细胞的分子靶向作用与肿瘤免疫治疗 | |
| 引用本文： | 赵刚,苏庆,李静,刘爱芹. 调节性T细胞的分子靶向作用与肿瘤免疫治疗[J]. 国际肿瘤学杂志, 2013, 40(6): 409-412 |
| 作者姓名： | 赵刚 苏庆 李静 刘爱芹 |
| 作者单位： | 山东省医学科学院药物研究所药剂研究室, 济南,250062 |
| 摘 要： | 调节性T细胞(Treg)具有免疫抑制功能,可通过在细胞表面表达细胞毒性T淋巴细胞相关抗原、穿孔素-颗粒酶介导的细胞毒作用、分泌细胞因子如白细胞介素-10(IL-10)、转化生长因子-β(TGF-β)等途径实现免疫抑制.采用抗体、疫苗和化学药物能够实现对FOXP3+CD25+CD4+调节性T细胞的靶向作用,使调节性T细胞在各种肿瘤患者外周血及肿瘤组织中的表达水平下调,降低其抑制免疫的功能,增强肿瘤免疫疗法的疗效. |
| 关 键 词： | 肿瘤 T淋巴细胞,调节性 免疫治疗 |
Targeting regulatory T cells and immunotherapy of tumor |
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| ZHAO Gang , SU Qing , LI Jing , LIU Ai-qin. Targeting regulatory T cells and immunotherapy of tumor[J]. Journal of International Oncology, 2013, 40(6): 409-412 | |
| Authors: | ZHAO Gang SU Qing LI Jing LIU Ai-qin |
| Affiliation: | Institute of Materia Medica, Shandong Academy of Medical Scince, Jinan 250062, China |
| Abstract: | Regulatory T cells (Tregs) possess the function of immune suppression and achieve immunosuppression by the approach of expressing cytotoxic T lymphocyte-associated antigen, perforin-particle enzyme mediated cytotoxic effect, and secretion of cytokines such as IL-10, TGF-β, et al. The antibodies, vaccines and chemical drugs can be applied for targeting FOXP3+CD25+CD4+Tregs, depleting Tregs in peripheral blood and tumor tissues of patients of various forms of cancers. The function of immune suppression can be decreased and antitumor curative effects by immunotherapy can be enhanced. |
| Keywords: | Neoplasmas T-lymphocytes cells,regulatory Immunotherapy |
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