| MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma |
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| 引用本文： | Cameron M Smith,David I Watson,Michael Z Michael,Damian J Hussey. MicroRNAs, development of Barrett’s esophagus, and progression to esophageal adenocarcinoma[J]. World journal of gastroenterology : WJG, 2010, 16(5). DOI: 10.3748/wjg.v16.i5.531 |
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| 作者姓名： | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey |
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| 作者单位： | Cameron M Smith,David I Watson,Damian J Hussey(Department of Surgery, Flinders University, Room 3D211, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia);Michael Z Michael(Department of Gastroenterology & Hepatology, Flinders University, Bedford Park, South Australia 5042, Australia) |
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| 摘 要： | Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esoph-ageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes. They have been implicated in most cellul...
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| 关 键 词： | Barrett’s esophagus MicroRNA Esophageal adenocarcinoma Transdifferentiation Tumour suppressor |
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma |
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| Cameron M Smith,David I Watson,Michael Z Michael,Damian J Hussey. MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma[J]. World journal of gastroenterology : WJG, 2010, 16(5). DOI: 10.3748/wjg.v16.i5.531 |
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| Authors: | Cameron M Smith David I Watson Michael Z Michael Damian J Hussey |
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| Affiliation: | 1. Department of Surgery, Flinders University, Room 3D211, Flinders Medical Centre, Bedford Park, South Australia 5042, Australia
2. Department of Gastroenterology & Hepatology, Flinders University, Bedford Park, South Australia 5042, Australia |
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| Abstract: | Barrett's esophagus is a premalignant condition caused by gastroesophageal reflux. Once developed, it can progress through varying grades of dysplasia to esophageal adenocarcinoma. Whilst it is well accepted that Barrett's esophagus is caused by gastroesophageal reflux, the molecular mechanisms of its pathogenesis and progression to cancer remain unclear. MicroRNAs (miRNAs) are short segments of RNA that have been shown to control the expression of many human genes.They have been implicated in most cellular processes, and the role of miRNAs in disease development is becoming increasingly evident. Understanding altered miRNA expression is likely to help unravel the molecular mechanisms that underpin the development of Barrett's esophagus and its progression to cancer. |
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| Keywords: | Barrett's esophagus MicroRNA Esophageal adenocarcinoma Transdifferentiation Tumour suppressor |
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