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| 乌司他丁对老年胸部肿瘤患者围术期细胞因子的影响 | |
| 引用本文： | 曹灵敏,马桂芬. 乌司他丁对老年胸部肿瘤患者围术期细胞因子的影响[J]. 泰山医学院学报, 2008, 29(4): 255-256 |
| 作者姓名： | 曹灵敏 马桂芬 |
| 作者单位： | 泰山医学院附属泰安医院麻醉科,山东,泰安,271000 |
| 摘 要： | 目的观察乌司他丁对老年胸部肿瘤患者围术期细胞因子的影响。方法30例择期食管癌和贲门癌根治术患者随机分为两组:乌司他丁组(U组),切皮前将乌司他丁30万单位稀释至100 ml生理盐水中30 min静脉输注;对照组(C组),以等量生理盐水代替。分别于麻醉前(T1)、手术结束(T2)、术后1(T3)、3(T4)、5(T5)天,采集外周静脉血,以放射免疫法测定血浆白细胞介素-6(IL-6)、白细胞介素-8(IL-8)及肿瘤坏死因子α(TNF-α)浓度。结果C组IL-6及TNF-α在T2、T3、T4时段均较T1明显升高(P<0.05);而U组IL-6及TNF-α浓度在T4已降至术前水平(P>0.05)。两组IL-6及TNF-α浓度比较在T2、T3、T4有显著性差异(P<0.05)。C组IL-8浓度在T2、T3较T1显著上升(P<0.05);而两组T2、T3时段IL-8比较有显著性差异(P<0.05)。结论老年胸部肿瘤患者术中应用乌司他丁能有效抑制围术期IL-6、IL-8、及TNF-α的释放。 |
| 关 键 词： | 乌司他丁 细胞因子 食管癌和贲门癌根治术 |
| 文章编号： | 1004-7115(2008)04-0255-02 |
| 修稿时间： | 2008-01-15 |
Effect of ulinastatin on perioprative cytokine in elderly patients with thoracic tumor |
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| CAO Ling-min,MA Gui-fen. Effect of ulinastatin on perioprative cytokine in elderly patients with thoracic tumor[J]. Journal of Taishan Medical College, 2008, 29(4): 255-256 | |
| Authors: | CAO Ling-min MA Gui-fen |
| Affiliation: | CAO Ling-min; MA Gui-fen(Taian City Central Hospital; Taian 271000; China); |
| Abstract: | Objective:To observe the effect of ulinastatin on perioprative cytokine in the elderly patients with thoracic tumor.Methods: Thirty patients undergone elective radical operation for esophogas and cardia cancer were randomly assigned into two groups with 15 cases each.The patients in the ulinastatn group(U) received ulinastatin 30ku in 30 min before skin incision,and the patients in the control group(C) the same volume of normal Saline as in group U instead of ulinastatin.Blood samples were taken before indu... |
| Keywords: | ulinastatin cytokine radical operation for esophogas and cardia cancer |
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