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| 脂联素对子宫内膜癌细胞生长抑制和细胞凋亡的影响 | |
| 引用本文： | 丛丽,王薇,李强,赵子建,张巾超. 脂联素对子宫内膜癌细胞生长抑制和细胞凋亡的影响[J]. 中华内分泌代谢杂志, 2010, 26(2). DOI: 10.3760/cma.j.issn.1000-6699.2010.02.017 |
| 作者姓名： | 丛丽 王薇 李强 赵子建 张巾超 |
| 作者单位： | 1. 哈尔滨医科大学附属第二医院内分泌科,150086 2. 美国匹兹堡大学医学院细胞生物与生理系 |
| 摘 要： | 观察脂联素对子宫内膜癌细胞株HEC-1-A和RL95-2细胞计数、细胞凋亡和细胞周期的影响,检测脂联素对细胞p-AMPK/AMPKα表达的影响.结果提示脂联素对子宫内膜癌细胞具有抑制生长和诱导细胞凋亡发生的作用,其作用机制可能与AMPK激活有关. |
| 关 键 词： | 脂联素 子宫内膜癌 细胞凋亡 AMP激活的蛋白激酶 |
Induction of apoptosis and cell cycle arrest in human endometrial cancer cells by adiponectin |
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| CONG Li,WANG Wei,LI Qiang,ZHAO Zi-jian,ZHANG Jin-chao. Induction of apoptosis and cell cycle arrest in human endometrial cancer cells by adiponectin[J]. Chinese Journal of Endocrinology and Metabolism, 2010, 26(2). DOI: 10.3760/cma.j.issn.1000-6699.2010.02.017 | |
| Authors: | CONG Li WANG Wei LI Qiang ZHAO Zi-jian ZHANG Jin-chao |
| Abstract: | Two human endometrial carcinoma cell lines, HEC-1-A and RL95-2, were treated with adiponectin,and then changes of cell count, apoptosis and cell cycle arrest were measured. The expression of phospho-AMPK(Thr172) and AMPK was determined by Western Blot. The results showed that adiponectin may exert direct anti-proliferative effects on HEC-1-A and RL95-2 cells by inducing cell cycle arrest and apoptosis, which may be mediated by AMPK pathway. |
| Keywords: | Adiponectin Endometrial carcinoma Apoptosis AMP-activated protein kinases |
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