| Preparation of Aminated Macroporous Polyvinyl Alcohol Resins and Evaluation for Bilirubin Adsorption |
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| 作者单位： | WANG Wei-chao,HU Yue-han,XIE Hui,YU Yao-ting,KONG De-ling(The Key Laboratory of Bioactive Materials,Ministry of Education,Nankai University,Tianjin 300071,China);ZHANG Sheng-nan,OU Lai-liang,GU Han-qing(Tianjin Medical University,Tianjin 300070,China) |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | In the present study we prepared macroporous polyvinyl alcohol beads. A series of bilirubin adsorbents were generated by immobilization of eight amine agents to the beads as ligands. The adsorption of bilirubin was evaluated by in vitro static and dynamic adsorption tests. The results show that these adsorbents have excellent adsorption efficiency and capacity. Among the eight ligands, trimethylamine (TMA), triethylamine (TEA) and 1,6- hexanediamine(HDA) showed the highest adsorption capacity. The adsorption equilibrium can be achieved in half an hour, and the adsorption percentage of bilirubin was up to 80%. Static electricity and hydrophobic interaction played the main role in bilirubin adsorption, and the adsorption was found to match the monolayer model. The excellent adsorption of these adsorbents indicates their potential in clinical treatment.
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Preparation of Aminated Macroporous Polyvinyl Alcohol Resins and Evaluation for Bilirubin Adsorption |
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| WANG Wei-chao,ZHANG Sheng-nan,HU Yue-han,XIE Hui,OU Lai-liang,YU Yao-ting,KONG De-ling,GU Han-qing. Preparation of Aminated Macroporous Polyvinyl Alcohol Resins and Evaluation for Bilirubin Adsorption[J]. Chinese Journal of Biomedical Engineering, 2008, 17(3) |
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| Authors: | WANG Wei-chao ZHANG Sheng-nan HU Yue-han XIE Hui OU Lai-liang YU Yao-ting KONG De-ling GU Han-qing |
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| Abstract: | In the present study we prepared macroporous polyvinyl alcohol beads. A series of bilirubin adsorbents were generated by immobilization of eight amine agents to the beads as ligands. The adsorption of bilirubin was evaluated by in vitro static and dynamic adsorption tests. The results show that these adsorbents have excellent adsorption efficiency and capacity. Among the eight ligands, trimethylamine (TMA), triethylamine (TEA) and 1,6- hexanediamine(HAD) showed the highest adsorption capacity. The adsorption equilibrium can be achieved in half an hour, and the adsorption percentage of bilirubin was up to 80%. Static electricity and hydrophobic interaction played the main role in bilirubin adsorption, and the adsorption was found to match the monolayer model. The excellent adsorption of these adsorbents indicates their potential in clinical treatment. |
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| Keywords: | macroporous polyvinyl alcohol resins aminated resins bilirubin adsorbent blood purification |
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