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| 大肠湿热型溃疡性结肠炎患者Toll-like2/4受体mRNA表达及溃结灵的干预作用 | |
| 引用本文： | 常东,黄志新,樊亚巍,陶永胜,李辉,何方,张东坡.大肠湿热型溃疡性结肠炎患者Toll-like2/4受体mRNA表达及溃结灵的干预作用[J].中国中医急症,2008,17(4):462-464. |
| 作者姓名： | 常东 黄志新 樊亚巍 陶永胜 李辉 何方 张东坡 |
| 作者单位： | 1. 武警广东边防总队医院,深圳,518029 2. 广州中医药大学脾胃研究所,广州,510407 3. 广东省深圳市中医院,深圳,518033 |
| 摘 要： | 目的探讨溃结灵颗粒配合柳氮磺胺吡啶（SASP）对大肠湿热型溃疡性结肠炎（UC）的作用机制。方法活动期UC（大肠湿热证）患者随机分为治疗组（溃结灵＋SASP）与对照组（SASP）,以RT-PCR方法检测治疗后肠黏膜组织内的TLR2/4mRNA表达的变化。结果病变组的TLR2/4 mRNA表达较正常对照组明显增强。治疗组治疗后较治疗前TLR2/4 mRNA表达明显减少;对照组治疗后较治疗前TLR2 mRNA表达有所减少,但无显著性差异,TLR4 mRNA表达明显减少。治疗组与对照组TLR2 mRNA表达治疗后差值比较有显著差异。治疗组与对照组的TLR2/4 mRNA表达治疗后差值比较亦有显著差异。结论溃结灵配合SASP治疗很可能是通过抑止TLR4、TLR2 mRNA表达,减弱了CD14和TLR2的协同作用,抑制TLR2依赖的脂蛋白信号转导,阻断TLR4蛋白,进而磷酸化激活κB的功能减弱,使损伤的内皮细胞得以修复,而达到治疗UC的作用。 |
| 关 键 词： | 溃疡性结肠炎 大肠湿热型 溃结灵 |
| 文章编号： | 1004-745X(2008)04-0462-03 |
| 修稿时间： | 2007年10月16 |
Changes of Toll-like Receptor 2/4 Gene Expression and Effects of Kuijieling Granules in the Patient of Ulcerative Colitis of Damp Heat in the Large Intestine Stagnation Type |
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| Institution: | CHANG Dong, HUANG Zhi-xin, FAN Ya-wei, et al( 1 Shenzhen Hospital of Armed Police( Shenzhen 518029; 2 Splenco- gastric Research Institute, Guangdong University of TCM (Guangzhou 510407) 3 Shenzhen Hospital of TCM ( Shenzhen 518033 ) |
| Abstract: | Objective： To study mechanism of Kuijieling Granules（KG） combined with SASP in treating ulcerative colitis（UC） . Methods： The patients of active UC （damp - heat syndrome） were randomly divided into 2 groups： KG ＋ SASP group and SASP group. The TLR2 - 4mRNA expression in all cases were detected by RT - PCR. Results： There were obvious inereasement of the expression of TLR2- 4 mRNA in the pathological changes group. The TLR2 - 4mRNA expression were decreased by KG ＋ SASP treatment . Conclusion： KG combined with SASP has definite effect on UC. it probably controls the gene expression of TLR2 - 4, singal conduction of BLP depend on by TLR2 and makes endothelial cells restored. |
| Keywords: | Ulcerative colitis Damp - heat syndrome Kuijieling Granules |
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