非小细胞肺癌组织血管内皮生长因子与色素上皮衍生因子表达程度对预后的影响

目的探讨在非小细胞肺癌（NSCLC）的细胞组织中，色素上皮衍生因子（PEDF）与血管内皮生长因子（VEGF）表达的特征性在NSCLC预后中的意义。方法选取50例NSCLC标本，免疫组化方法检测VEGF、PEDF和CD31抗体免疫组化染色，并计数微血管密度。结果PEDF和VEGF在肺癌组织中的阳性率分别为44．00％和64．00％。PEDF、VEGF表达与病理分级、淋巴结远处转移、临床分期有关。VEGF表达阴性的患者生存率明显高于表达阳性患者；而PEDF表达阴性的患者生存率明显低于表达阳性患者。结论VEGF和PEDF的表达可以判断NSCLC的淋巴结转移和血管生成等生物学行为以及评估NSCLC患者的预后。

Influences of Expression of Vascular Endothelial Growth Factor and Pigment Epithelium Derived Factor in Non-Small Cell

Objective To research the significance of characteristic expression of pigment epithelium derived factor （PEDF） and vascular endothelial growth factor （VEGF） in non-small cell lung cancer （NSCLC） tissue on the prognosis of NSCLC. Methods The specimens were from 50 NSCLC patients. Immunohistochemistry method was used to detect the immunohistochemical staining of VEGF, PEDF and CD31, and microvessel density （MVD） was calculated. Results The positive rates of VEGF and PEDF in lung cancer tissues were respectively 64.00% and 44. 00 %, and their expressions were related to pathological grades, distal metastasis of lymph nodes and clinical staging. The survival rate of patients with positive VEGF expression was obviously lower than those with negative VEGF expression,whereas the survival rate of patients with positive PEDF expression was significantly higher than those with negative PEDF expression. Conclusion VEGF and PEDF expression can be used as the indexes for detecting the biological behaviors like angiogenesis,invasion and metastasis from lymph nodes of NSCLC,and can also be used to assess the prognosis of NSCLC patients.