Effect of decreasing the dose rate of irradiation on the mouse lip mucosa. Comparison with fractionated irradiations |
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| Authors: | P Scalliet W Landuyt E van der Schueren |
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| Affiliation: | 1. Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, The Netherlands;2. Department of Radiation Oncology (MAASTRO Clinic), GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, The Netherlands;3. Radiotherapeutic Institute Friesland, Leeuwarden, The Netherlands;4. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, The Netherlands;1. Radiation Oncology Department, AO. S. Croce e Carle, Cuneo, Italy;2. Department of Radiotherapy, University of Turin, Italy;3. Departmento of Oncology, Ospedale San Paolo, Savona, Italy;4. Radio-Oncology Department, IRCCS San Martino – IST, Largo R Benzi 10, 16132 Genoa, Italy;5. Department of Radiotherapy, University “La Sapienza”, Rome Italy;6. Medical Oncology Unit, Ospedale U. Parini, Viale Ginevra 3, 11100 Aosta, Italy;7. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy;8. Radiation Oncology Department, University of Brescia and Spedali Civili, Brescia, Italy;9. Nurse Department of ENT Molinette Hospital, Turin, Italy;10. Department of Oncology, Azienda Ospedaliera Citta’ Della Salute E Della Scienza Di Torino, Italy;11. Medical Oncology Department, AO. S. Croce e Carle, Cuneo, Italy;12. Radiation Oncology Department, Unit of University of Messina, Italy;13. Medical Oncology Unit, Azienda Ospedaliero-Universitaria di Parma Maggiore Hospital, Via Gramsci, 14 43100 Parma, Italy;14. Department of Radiation Oncology, CHU Poitiers, Poitiers Cedex, France;15. Department of Medicine, Section of Dermatology and Venereology, University of Verona, Verona, Italy;p. Department of Radiation Oncology, University Medical Center Groningen, The Netherlands;1. Lab of Action & Body, Department of Psychology, Royal Holloway, University of London, TW20 0EX Egham, Surrey, UK;2. Interdisciplinary Center for Obesity and Bariatrics (C.I.B.O.), Istituti Clinici Zucchi, via Zucchi 24, 20052 Monza, Italy;3. Emotifood Body Image & Eating Disorders Unit, via Palestro, 12, 20900 Monza, Italy;4. Laboratory of Cognitive Neuroscience, Center for Neuroprosthetics, Ecole Polytechnique Fédérale de Lausanne, Campus Biotech, CH-1202 Genève, Switzerland;1. Institute for Geosciences, Goethe University Frankfurt, Section Mineralogy, Petrology and Geochemistry, Altenhöferallee 1, D-60438 Frankfurt, Germany;2. Section of Earth and Environmental Sciences, University of Geneva, Rue des Maraichers 13, CH-1205 Geneva, Switzerland;3. School of Geosciences, University of the Witwatersrand, Johannesburg, 2050, South Africa;1. Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, The Netherlands;2. Department of Radiation Oncology, Erasmus University Medical Center, Rotterdam, The Netherlands;3. Department of Radiation Oncology, Netherlands Cancer Institute/Antoni van Leeuwenhoek, Amsterdam, The Netherlands;4. Department of Radiation Oncology, Amsterdam University Medical Center, The Netherlands;5. Department of Radiation Oncology, University Medical Center Groningen,, The Netherlands;6. Department of Radiation Oncology, Maastricht University Medical Center (MAASTRO), The Netherlands |
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| Abstract: | ![]()
The effect of continuous irradiation, delivered at five different dose rates (642, 76.8, 14.1, 2.9 and 1.5 Gy.h-1), has been investigated using the mouse lip mucosa. There was a striking dose rate effect (DRE) below 14.1 Gy.h-1 while above this dose rate the DRE was relatively small. No DRE was observed between irradiations delivered at 642 and 76.8 Gy.h-1. A comparison was made with the previously published results of high dose rate (84 Gy.h-1) fractionated irradiation (2, 4, 10 and 20 fractions). For both types of irradiation treatment an alpha/beta value of 7.4 Gy and a half-time for repair of 47 min was derived. |
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