| 固体自乳化药物传递系统的研究概况 |
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| 引用本文： | 程玉钏,周建平,吕慧侠,张振海.固体自乳化药物传递系统的研究概况[J].药学进展,2008,32(2):68-75. |
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| 作者姓名： | 程玉钏 周建平 吕慧侠 张振海 |
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| 作者单位： | 中国药科大学药剂学教研室,江苏,南京,210009 |
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| 摘 要： | 综述固体自乳化药物传递系统的定义与特点、处方组分、制备工艺、药物体外释放和体内吸收的影响因素及质量评价指标。固体自乳化药物传递系统为一种新型制剂，可以显著提高难溶性药物的口服生物利用度，还可以通过添加各种固体辅料或采用包衣技术制备缓控释产品。
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| 关 键 词： | 固体自乳化药物传递系统 难溶性药物 口服生物利用度 |
| 文章编号： | 1001-5094（2008）02-0068-08 |
| 收稿时间： | 2007-11-07 |
| 修稿时间： | 2007年11月7日 |
An Overview of Solid Self-emulsifying Drug Delivery System |
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| CHENG Yu-chuan,ZHOU Jian-ping,Lü Hui-xia,ZHANG Zhen-hai.An Overview of Solid Self-emulsifying Drug Delivery System[J].Progress in Pharmaceutical Sciences,2008,32(2):68-75. |
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| Authors: | CHENG Yu-chuan ZHOU Jian-ping Lü Hui-xia ZHANG Zhen-hai |
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| Institution: | (Department of Pharmaceutics , China Pharnuweutical University, Nanjing 210009, China) |
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| Abstract: | The characterization, formulation and preparation of the solid self-emulsifying drug delivery system, as well as the effect factors on the system and the evaluation index of it were expatiated. The oral bioavailability of water-insoluble drugs can be enhanced significantly by the utilization of the solid self-emulsi-fying drug delivery system. Furthermore, modified-release preparations can be achieved more easily by adding various kinds of solid excipients or by the application of coating techniques. |
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| Keywords: | Solid self-emulsifying drug delivery system Water-insoluble drugs Oral bioavailability |
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