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Use of supplementary phenotype to identify additional rheumatoid arthritis loci in a linkage analysis of 342 UK affected sibling pair families |
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| Authors: | Bamidele O Tayo Yulan Liang Arpad Kelemen Austin Miller Maurizio Trevisan Richard S Cooper |
| Affiliation: | (1) Department of Preventive Medicine and Epidemiology, Loyola University Chicago, Chicago, IL, USA;(2) Department of Family and Community Health, University of Maryland, Baltimore, MD, USA;(3) Department of Organizational System and Adult Health, University of Maryland, Baltimore, MD, USA;(4) Departments of Biostatistics, State University of New York at Buffalo, Buffalo, NY, USA;(5) University of Nevada Health Sciences System, Las Vegas, NV, USA |
| Abstract: | BackgroundAlthough rheumatoid arthritis has been shown to have moderately strong genetic component, both linked loci identified in linkage analyses and susceptibility variants from association studies are short of adequately accounting for a comprehensive catalogue of the molecular factors underlying this complex disease. The objective of this study was to use supplementary phenotype based on cumulative hazard of rheumatoid arthritis to identify linkage evidence for new and additional rheumatoid arthritis loci in a genome-wide linkage analysis of 342 affected sibling pair families from the United Kingdom. |
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