锗元素与抗肿瘤药物(Ⅱ)(续上期)

综述了有机锗抗肿瘤药物，对β－羧乙基锗倍半氧化物（Ｇｅ－１３２）和螺锗在肿瘤学中的作用以及抗癌效应机制作出评价。自８０年代起至今，又有含硫杂、柠檬酸、氨基酸、苯基的锗化合物，以及锗酵母、含锗中草药等被先后合成出来。在几类具有生物活性的有机锗化合物中，仍首推Ｇｅ－１３２，螺锗及其衍生物为低毒有效抗肿瘤候选药物，然而对于锗导致的毒性及其机理仍需进一步加以探讨。

Germanium and antineoplastic agents

Organogermanium compounds in antineoplastic-agents were reviewed.The effects of 2-carboxyethyl germanium sesquioxide(Ge-132) and spirogermanium in oncology and mechanisms of antineoplastic action were evaluated.Some other organogermanium compounds have been syn-thesized,such as sulfur-containing,citrate-,amino acid-,phenyl-,Ge-yeast,or Ge-mixed Chinese medicinal herb,since 80′s.up to date,Ge-132 and spirogermanium compounds are hopeful to use as antineopla-stic-agents in the prevention and cure of different neoplasms,among the several organogermanium compounds,which have biological activity.However,their mechanisms of Ge-induced toxicity in human are still in pursuing cautiously.