Elevated antibody to D-alanyl lipoteichoic acid indicates caries experience associated with fluoride and gingival health |
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| Authors: | Martin Levine Robert L Brumley Kevin T Avery Willis L Owen Donald E Parker |
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| Affiliation: | (1) Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190, USA;(2) Department of Community Dentistry, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190, USA;(3) Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center, P.O. Box 26901, Oklahoma City, OK 73190, USA;(4) GenSys Technologies Inc., 9155 Little Farm Dr White, Lake, MI, 48386 |
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| Abstract: | ![]()
Background Acidogenic, acid-tolerant bacteria induce dental caries and require D-alanyl glycerol lipoteichoic acid (D-alanyl LTA) on their cell surface. Because fluoride inhibits acid-mediated enamel demineralization, an elevated antibody response to D-alanyl LTA may indicate subjects with more acidogenic bacteria and, therefore, an association of DMFT with fluoride exposure and gingival health not apparent in low responders. |
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