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| 外膜囊泡医学应用研究进展 | |
| 引用本文： | 李笋,戚远通,苟强,张卫军,左钱飞,邹全明. 外膜囊泡医学应用研究进展[J]. 免疫学杂志, 2021, 0(2): 179-184 |
| 作者姓名： | 李笋 戚远通 苟强 张卫军 左钱飞 邹全明 |
| 作者单位： | 解放军第九六八医院卫勤处;陆军军医大学药学与检验医学系药剂学教研室;陆军军医大学 |
| 基金项目： | 重庆市自然科学基金面上项目(csct2019jcyjmsxmX0496);国家自然科学基金面上项目(319708771004641)。 |
| 摘 要： | 外膜囊泡(OMV)是细菌自然生长的产物,呈球形双层膜纳米结构,其表面包含众多PAMPs,与免疫应答相关.OMV具有免疫原性和固有佐剂活性,因此可作为疫苗或单独的疫苗佐剂使用.OMV的中空结构可以作为药物储存载体,同时利用其外部结构实现药物的靶向作用.OMV在医学领域研究甚广,但要充分发挥其功能须清楚了解其研究进展和作用... |
| 关 键 词： | 外膜囊泡 疫苗 佐剂 载体 肿瘤 应用 |
The research progress of outer membrane vesicles |
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| LI Sun,QI Yuantong,GOU Qiang,ZHANG Weijun,ZUO Qianfei,ZOU Quanming. The research progress of outer membrane vesicles[J]. Immunological Journal, 2021, 0(2): 179-184 | |
| Authors: | LI Sun QI Yuantong GOU Qiang ZHANG Weijun ZUO Qianfei ZOU Quanming |
| Affiliation: | (Department of Medical Services,the 968th Hospital of PLA,Jinzhou 121000,China;Department of Pharmacy,Army Medical University,Chongqing 400038,China;Department of Microbiology and Biochemical Pharmacy,Army Medical University,Chongqing 400038,China) |
| Abstract: | Outer membrane vesicle(OMV),a natural growth product of bacteria,is a spherical double-layered nanostructure with a surface containing numerous PAMPs,and associates the immune responses.OMV has immunogenicity and intrinsic adjuvant activity,thus can be used as vaccine and adjuvant.The hollow structure of OMV can be used as a drug storage and transport carrier,and its external structure can be used to achieve drug targeting.OMV has been widely studied in the field of medicine,and it is necessary to understand its research progress and mechanism of action.In this paper,the medical application of OMV is briefly reviewed,so that researchers in this field can quickly obtain progress information. |
| Keywords: | Outer membrane vesicle Vaccine Adjuvant Carrier Cancer Application |
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