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| 磁导向纳米磁微粒栓塞脑动静脉畸形的实验研究 | |
| 引用本文： | 于耀宇,李建,李立宏,曲友直,于嘉,邓建平,赵振伟,高国栋,张文彬,魏孟广. 磁导向纳米磁微粒栓塞脑动静脉畸形的实验研究[J]. 中国临床神经外科杂志, 2011, 16(12): 735-737. DOI: 10.3969/j.issn.1009-153X.2011.12.011 |
| 作者姓名： | 于耀宇 李建 李立宏 曲友直 于嘉 邓建平 赵振伟 高国栋 张文彬 魏孟广 |
| 作者单位： | 1. 第四军医大学唐都医院神经外科,西安,710038 2. 300162天津,中国人民武装警察部队医学院附属医院神经外科 |
| 基金项目： | 国家自然科学基金，天津市自然科学基金 |
| 摘 要： | 目的探讨磁导向纳米磁微粒定向栓塞脑动静脉畸形(CAVM)的有效性和可靠性。方法将建立了CAVM模型的15头小猪随机分为3组:磁导向组(聚焦磁场导向,n=6),非磁导向组(无聚焦磁场导向,n=6)和对照组(不做任何处理n=3),前两组均采用纳米磁微粒栓塞CAVM。分别在栓塞后1周进行DSA和B超声检查,观察栓塞效果。结果磁导向组在栓塞1周后DSA显示,CAVM和引流静脉几乎全部消失。术后1周B超示引流静脉无血流,右侧颈静脉血栓形成;平均流速为0,与非磁导向组的(70.22±2.26)cm/s和对照组的(75.53±2.24)cm/s相比,差异显著(P<0.01)。结论实验证实在磁场作用下,纳米磁微粒可以有效地、可靠地靶向栓塞小猪的CAVM。这可能为临床治疗CAVM提供了新的途径和栓塞材料。 |
| 关 键 词： | 脑动静脉畸形 模型 纳米磁微粒 定向栓塞 小猪 |
Magnetism-guided endovascular embolization of cerebral arteriovenous mafformations by magnetic nanoparticles in pigs |
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| YU Yao-yu,LI Jian,LI Li-hong,QU You-zhi,YU jia,DENG Jian-ping,ZHAO Zhen-wei,GAO Guo-dong,ZHANG Wen-bin,WEI Meng-guang. Magnetism-guided endovascular embolization of cerebral arteriovenous mafformations by magnetic nanoparticles in pigs[J]. Chinese Journal of Clinical Neurosurgery, 2011, 16(12): 735-737. DOI: 10.3969/j.issn.1009-153X.2011.12.011 | |
| Authors: | YU Yao-yu LI Jian LI Li-hong QU You-zhi YU jia DENG Jian-ping ZHAO Zhen-wei GAO Guo-dong ZHANG Wen-bin WEI Meng-guang |
| Affiliation: | YU Yao-yu,LI Jian,LI Li-hong,QU You-zhi,YU Jia,DENG Jian-ping,ZHAO Zhen-wei,GAO Guo-dong,ZHANG Wen-bin,WEI Meng-guang.Department of Neurosurgery,Tangdu Hospital,The Fourth Military Medical University,Xi'an 710038,China |
| Abstract: | Objective To explore the reliability and effectiveness of magnetism-guided endovascular embolization of the cerebral arteriovenous malformations(CAVM) by magnetic albumin nanoparticles(MAN).Methods Fifteen pigs with CAVM established by Massoud method were divided into three groups,i.e.Magnetism-guided(with focusing magnetic field) group(n=6),no magnetism-guided(without focusing magnetic field) group(n=6) and control(without any treatment) group(n=3).CAVM were endovascularly embolized by MAN in the animals o... |
| Keywords: | Cerebral arteriovenous malformation Magnetic nanoparticles Magnetism Guidance Pig |
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