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| 28醇对6-羟基多巴胺致帕金森病大鼠模型行为学的改善作用 | |
| 引用本文： | 王涛,刘亚静,刘雁勇,杨楠,纪超,陈彪,左萍萍. 28醇对6-羟基多巴胺致帕金森病大鼠模型行为学的改善作用[J]. 中国康复理论与实践, 2011, 17(11): 1025-1027 |
| 作者姓名： | 王涛 刘亚静 刘雁勇 杨楠 纪超 陈彪 左萍萍 |
| 作者单位： | 1. 首都医科大学宣武医院神经生物学研究室,北京市,100053 2. 中国医学科学院基础医学研究所药理室,北京市,100005 |
| 基金项目： | 国家973基金项目，2.国家自然科学基金项目 |
| 摘 要： | 目的 检测28醇对6-羟基多巴胺(6-OHDA)致帕金森病(PD)大鼠模型的作用.方法 将大鼠分为假手术组(n=1 5)、模型组(n=15)、低剂量组(n=12)、中剂量组(n=12)和高剂量组(n=12).将6-OHDA注人大鼠右侧纹状体制备PD模型,治疗组分别以28醇17.5 mg/kg、35 mg/kg、70 m... |
| 关 键 词： | 帕金森病 28醇 6-羟基多巴胺 行为学 大鼠 |
Effects of Octacosanol on Behavioral Impairments in Rats with Parkinson's Disease Induced by 6-hydroxydopamine |
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| WANG Tao,LIU Ya-jing,LIU Yan-yong,et al.. Effects of Octacosanol on Behavioral Impairments in Rats with Parkinson's Disease Induced by 6-hydroxydopamine[J]. Chinese Journal of Rehabilitation Theory and Practice, 2011, 17(11): 1025-1027 | |
| Authors: | WANG Tao LIU Ya-jing LIU Yan-yong et al. |
| Affiliation: | WANG Tao,LIU Ya-jing,LIU Yan-yong,et al.Department of Neurobiology,Beijing Institute of Geriatrics,Xuanwu Hospital,Capital Medical University,Beijing 100053,China |
| Abstract: | Objective To explore the effects of octacosanol on the behavioral impairments in rats with Parkinson's disease(PD) induced by 6-hydroxydopamine(6-OHDA).Methods The SD rats were divided into the control group(n=15),the model group(n=15),the low dose group(n=12),the medium dose group(n=12) and the high dose group(n=12).6-OHDA was stereotactically injected into the right striatum of the rats at 2 sites to produce PD models.The treatment groups received octacosanol with the dose of 17.5 mg/kg,35 mg/kg or 70 mg/... |
| Keywords: | Parkinson's disease octacosanol 6-hydroxydopamine behavioral tests rats |
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