| 银杏叶提取物对CYP酶的影响及与其他药物的相互作用 |
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| 引用本文： | 左笑丛,刘玉兰,吴翠芳,彭向东,裴奇,刘世坤. 银杏叶提取物对CYP酶的影响及与其他药物的相互作用[J]. 中国新药与临床杂志, 2008, 27(1): 64-69 |
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| 作者姓名： | 左笑丛 刘玉兰 吴翠芳 彭向东 裴奇 刘世坤 |
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| 作者单位： | 中南大学湘雅三医院药剂科,湖南,长沙,410013 |
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| 摘 要： | 综述了近年来银杏叶提取物(Ginkgo biloba extract)与其他药物相互作用的研究进展。研究表明银杏叶提取物在大鼠体内和人体内外对CYP酶的影响不一致。人体内银杏叶提取物对药物代谢酶CYP 2C19和CYP 2E1有诱导作用,分别增强了美芬妥因、奥美拉唑和氯唑沙宗的代谢。银杏叶提取物通过降低血中超氧化物歧化酶水平而发挥抗氧化作用,提高了抗精神病药物的疗效。银杏叶提取物还可能与阿司匹林、华法林和曲唑酮等发生药效学方面的相互作用,在临床应用中要引起重视。因此,需要进一步在人体内研究银杏叶提取物与其他药物的相互作用。
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| 关 键 词： | 银杏叶提取物 细胞色素P450 药物相互作用 |
| 文章编号： | 1007-7669（2008）01-0064-06 |
| 收稿时间： | 2006-12-14 |
| 修稿时间： | 2007-12-02 |
Effects of Ginkgo biloba extract on CYP and drug interactions with other drugs |
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| ZUO Xiao-cong,LIU Yu-lan,WU Cui-fang,PENG Xiang-dong,PEI Qi,LIU Shi-kun. Effects of Ginkgo biloba extract on CYP and drug interactions with other drugs[J]. Chinese Journal of New Drugs and Clinical Remedies, 2008, 27(1): 64-69 |
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| Authors: | ZUO Xiao-cong LIU Yu-lan WU Cui-fang PENG Xiang-dong PEI Qi LIU Shi-kun |
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| Abstract: | The advances in drug interactions with Ginkgo biloba extract are reviewed.The investigations indicate that the effects of Ginkgo biloba extract on cytochrome P450 in rats,in vitro and in vivo are inconsistent.In human Ginkgo biloba extract induce the activity of CYP 2C19 and CYP 2E1 and thus increase the metabolism of mephenetoin,omeprazole and chlorzoxazone.Ginkgo biloba extract might enhance the efficiency of antipsychotic in patients with schizophrenia by reducing serum superoxide dismutase(SOD)levels. The pharmacodynamic interactions between Ginkgo biloba extract and aspirin,warfarin,trazodone should be paid more attention. |
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| Keywords: | Ginkgo biloba extract cytochrome P-450 drug interactions |
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