| 多重靶向的4-取代苯胺喹唑啉类衍生物抗肿瘤活性研究进展 |
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| 引用本文： | 龚飞虎,孙丽萍. 多重靶向的4-取代苯胺喹唑啉类衍生物抗肿瘤活性研究进展[J]. 药学进展, 2014, 0(1): 25-30 |
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| 作者姓名： | 龚飞虎 孙丽萍 |
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| 作者单位： | 中国药科大学药物化学教研室,江苏南京210009 |
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| 基金项目： | 国家自然科学基金资助项目（No.21172265）;江苏省高校“青蓝工程”项目 |
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| 摘 要： | 4-取代苯胺喹唑啉类化合物是喹唑啉类酪氨酸激酶抑制剂中活性较高的一类化合物，其对表皮生长因子受体、血管内皮生长因子受体、组蛋白去乙酰化酶等均有抑制作用，已成为抗肿瘤药物的研究热点。综述了近几年多重靶向的4-取代苯胺喹唑啉类化合物抗肿瘤活性的研究进展。
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| 关 键 词： | 4-取代苯胺喹唑啉 人类表皮生长因子受体 血管内皮生长因子受体 组蛋白去乙酰化酶 多靶向 抗肿瘤活性 |
Research Progresses in Antitumor Activity of Multiple Target 4-Substituted Anilinoquinazoline Derivatives |
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| GONG Feihu,SUN Liping. Research Progresses in Antitumor Activity of Multiple Target 4-Substituted Anilinoquinazoline Derivatives[J]. Progress in Pharmaceutical Sciences, 2014, 0(1): 25-30 |
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| Authors: | GONG Feihu SUN Liping |
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| Affiliation: | (Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China) |
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| Abstract: | 4-Substituted anilinoquinazoline derivatives are a class of compounds with high activities in quinazoline tyrosine kinase inhibitors. They can inhibit the epidermal growth factor receptor （EGFR）, vascular endothelial growth factor receptor （VEGFR） and histone deacetylase （HDAC）. These compounds have become a research hotspot of antitumor drugs. The advances in research on antitumor bioactivity of 4-substituted anilinoquinazoline derivatives with multiple targets have been reviewed in this paper. |
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| Keywords: | 4-substituted anilinoquinazoline human epidermal growth factor receptor vascular endothelial growth factor receptor histone deacetylase multiple target antitumor bioactivity |
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